微小RNA与肿瘤坏死因子-α对成骨分化调控作用研究进展

摘要/Abstract

摘要： ［摘要］目前口腔临床中牙周炎的发病率日益升高，炎症环境中肿瘤坏死因子-α(TNF-α)和微小RNA (microRNAs, miRNAs)可对成骨分化各个阶段产生调控作用。本文就miRNAs和TNF-α对成骨分化的调控作用作一综述。

关键词: 微小RNA, 肿瘤坏死因子-α, 成骨分化

Abstract: Abstract: Periodontitis often result in massive bone destruction and show increased incidences especially in elderly population. As one of the highly-expressed inflammatory mediators, tumor necrosis factor-alpha (TNF-α), together with a certain group of microRNAs (miRNAs), have recently been shown to play important roles in regulating osteogenic differentiation in inflammatory microenvironment. This review summarized progresses in the understanding of the molecular mechanisms underlying the regulatory effets of microRNA and TNF-α on osteogenic differentiation.

Key words: microRNA, tumor necrosis factor-alpha, osteogenic differentiation

中图分类号:

R780.2

李珊珊张瑾. 微小RNA与肿瘤坏死因子-α对成骨分化调控作用研究进展[J]. , 2017, 37(2): 180-183.

参考文献

[1]Lian JB,Stein GS,van Wijnen AJ,et al.MicroRNA control of bone formation and homeostasis[J].Nat Rev Endocrinol,2012,8(4):212-227
[2]Wang Q,Cai J,Cai XH,et al.miR-346 regulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the Wnt/beta-catenin pathway[J].PLoS One,2013,8(9):e72266-
[3]Zhang J,Tu Q,Bonewald L F,et al.Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1[J].J Bone Miner Res,2011,26(8):1953-1963
[4]Hassan MQ,Maeda Y,Taipaleenmaki H,et al.miR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of Metastatic Cancer Cells[J].Journal of Biological Chemistry,2012,287(50):42084-42092
[5]Mizuno Y,Tokuzawa Y,Ninomiya Y,et al.miR-210 promotes osteoblastic differentiation through inhibition ofAcvR1b[J].FEBS Letters,2009,583(13):2263-2268
[6]Bhushan R,Grunhagen J,Becker J,et al.miR-181a promotes osteoblastic differentiation through repression of TGF-beta signaling molecules[J].Int J Biochem Cell Biol,2013,45(3):696-705
[7]Song Q,Zhong L,Chen C,et al.miR-21 synergizes with BMP9 in osteogenic differentiation by activating the BMP9/Smad signaling pathway in murine multilineage cells[J].Int J Mol Med,2015,36(6):1497-1506
[8]Huang J,Zhao L,Xing L,et al.MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation[J].Stem Cells,2010,28(2):357-364
[9]Hu R,Liu W,Li H,et al.A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation[J].J Biol Chem,2011,286(14):12328-12339
[10]Taipaleenmaki H,Bjerre HL,Chen L,et al.Mechanisms in endocrinology: micro-RNAs: targets for enhancing osteoblast differentiation and bone formation[J].Eur J Endocrinol,2012,166(3):359-371
[11]Eskildsen T,Taipaleenmaki H,Stenvang J,et al.MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo[J].Proc Natl Acad Sci U S A,2011,108(15):6139-6144
[12]Bae Y,Yang T,Zeng HC,et al.miRNA-34c regulates Notch signaling during bone development[J].Human Molecular Genetics,2012,21(13):2991-3000
[13]Itoh T,Nozawa Y,Akao Y.MicroRNA-141 and -200a Are Involved in Bone Morphogenetic Protein-2-induced Mouse Pre-osteoblast Differentiation by Targeting Distal-less Homeobox 5[J].J Bio Chemist,2009,284(29):19272-19279
[14]Qadir A S,Um S,Lee H,et al.miR-124 Negatively Regulates Osteogenic Differentiation and In vivo Bone Formation of Mesenchymal Stem Cells[J].Journal of Cellular Biochemistry,2015,116(5):730-742
[15]Li J,He X,Wei W,et al.MicroRNA-194 promotes osteoblast differentiation via downregulating STAT1[J].Biochemical and Biophysical Research Communications,2015,460(2):482-488
[16]Kapinas K,Kessler C B,Delany A M.miR-29 suppression of osteonectin in osteoblasts: Regulation during differentiation and by canonical Wnt signaling[J].Journal of Cellular Biochemistry,2009,108(1):216-224
[17]Inose H,Ochi H,Kimura A,et al.A microRNA regulatory mechanism of osteoblast differentiation[J].Proc Natl Acad Sci U S A,2009,106(49):20794-20799
[18]Jing D,Hao J,Shen Y,et al.The role of microRNAs in bone remodeling[J].Int J Oral Sci,2015,7(3):131-143
[19]Osta B,Benedetti G,Miossec P.Classical and Paradoxical Effects of TNF-α on Bone Homeostasis[J].Frontiers in Immunology,2014,5:48-
[20]Lee H L,Yi T,Baek K,et al.Tumor necrosis factor-alpha enhances the transcription of Smad ubiquitination regulatory factor 1 in an activating protein-1- and Runx2-dependent manner[J].J Cell Physiol,2013,228(5):1076-1086
[21]Lu X,Beck G J,Gilbert L C,et al.Identification of the homeobox protein Prx1 (MHox,Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor alpha action in osteoblast differentiation[J].J Bone Miner Res,2011,26(1):209-219
[22]Ding J,Ghali O,Lencel P,et al.TNF-alpha and IL-1beta inhibit RUNX2 and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells[J].Life Sci,2009,84(15-16):499-504
[23]Lee H L,Yi T,Woo K M,et al.Msx2 mediates the inhibitory action of TNF-alpha on osteoblast differentiation[J].Exp Mol Med,2010,42(6):437-445
[24]陈小燕，丁寅，金岩.TNF-α通过NF-κB信号通路对人牙周膜干细胞成骨分化调控作用的研究[J].口腔生物医学,2015,(03):124-128
[25]Kong X,Liu Y,Ye R,et al.GSK3β is a checkpoint for TNF-α-mediated impaired osteogenic differentiation of mesenchymal stem cells in inflammatory microenvironments[J].Biochimica et Biophysica Acta (BBA) - General Subjects,2013,1830(11):5119-5129
[26]Diarra D,Stolina M,Polzer K,et al.Dickkopf-1 is a master regulator of joint remodeling[J].Nat Med,2007,13(2):156-163
[27]Yu R Y,Zeng B J,Liu Y S,et al.[Recombinant human tumor necrosis factor-alpha promotes human adipose-derived stromal cells transforming into osteoblast in vitro][J].Beijing Da Xue Xue Bao,2012,44(3):475-480
[28]Feng X,Feng G,Xing J,et al.TNF-alpha triggers osteogenic differentiation of human dental pulp stem cells via the NF-kappaB signalling pathway[J].Cell Biol Int,2013,37(12):1267-1275
[29]Hess K,Ushmorov A,Fiedler J,et al.TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway[J].Bone,2009,45(2):367-376
[30]Briolay A,Lencel P,Bessueille L,et al.Autocrine stimulation of osteoblast activity by Wnt5a in response to TNF-alpha in human mesenchymal stem cells[J].Biochem Biophys Res Commun,2013,430(3):1072-1077
[31]Li C,Zhang P,Gu J.miR-29a modulates tumor necrosis factor-αinduced osteogenic inhibition by targeting Wnt antagonists[J].Development,Growth & Differentiation,2015,57(3):264-273
[32] Wang N,Zhou Z,Wu T,et al.TNF-alpha-induced NF-kappaB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting beta-catenin[J]. Open Biol,2016,6(3)
[33]Mi W,Shi Q,Chen X,et al.miR-33a-5p modulates TNF-alpha-inhibited osteogenic differentiation by targeting SATB2 expression in hBMSCs[J].FEBS Lett,2016,590(3):396-407
[34]Liu Y,Liu W,Hu C,et al.MiR-17 Modulates Osteogenic Differentiation Through a Coherent Feed-Forward Loop in Mesenchymal Stem Cells Isolated from Periodontal Ligaments of Patients with Periodontitis[J].STEM CELLS,2011,29(11):1804-1816
[35]Yang N,Wang G,Hu C,et al.Tumor necrosis factor α suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency-induced osteoporosis[J].Journal of Bone and Mineral Research,2013,28(3):559-573
[36]Liao L,Su X,Yang X,et al.TNF-alpha Inhibits FoxO1 by Upregulating miR-705 to Aggravate Oxidative Damage in Bone Marrow-Derived Mesenchymal Stem Cells during Osteoporosis[J].Stem Cells,2016,34(4):1054-1067