外用重组人表皮生长因子联合硫酸羟氯喹片治疗糜烂型口腔扁平苔藓的疗效观察

›› 2017, Vol. 37 ›› Issue (7): 632-634.

外用重组人表皮生长因子联合硫酸羟氯喹片治疗糜烂型口腔扁平苔藓的疗效观察

陈蕙萍¹,陈月来²

1. 上海市同仁医院上海交通大学医学院附属同仁医院
2. 上海交通大学附属同仁医院

收稿日期:2016-03-22 修回日期:2016-07-25 出版日期:2017-07-28 发布日期:2017-07-18
通讯作者: 陈蕙萍 E-mail:doctor_liuliu@126.com

Efficacy observation of rhEGF with hydroxychloroquine tablets in treating erosive oral lichen planus

Hui-Ping CHENG ²

Received:2016-03-22 Revised:2016-07-25 Online:2017-07-28 Published:2017-07-18
Contact: Hui-Ping CHENG E-mail:doctor_liuliu@126.com

摘要/Abstract

摘要： 【摘要】　目的观察外用重组人表皮生长因子（rhEGF）与硫酸羟氯喹片治疗糜烂型口腔扁平苔藓的临床疗效。方法将口腔扁平苔藓患者60例随机分成两组，治疗组30例，使用外用重组人表皮生长因子与硫酸羟氯喹片，对照组30例，单独使用口腔硫酸羟氯喹片，治疗3个月后及停药3个月后复诊按3级疗效标准评定总体疗效。结果治疗组与对照组治疗3个月后的总有效率分别为93.33％和48.30%，。停药3个月后复诊总有效率分别为91.23％和40.63％，两组均有统计学差异（P<0.05）。结论：外用重组人表皮生长因子与硫酸羟氯喹片联合应用治疗口腔扁平苔藓有良好的临床疗效。

关键词: 外用重组人表皮生长因子硫酸羟氯喹片口腔扁平苔藓

Abstract: Abstract： Objective To evaluate the clinical effect of rhECF’s with hydroxychloroquine tablets (Plaquenil) on erosion oral lichen planus. Methods 60 cases with erosive oral lichen planus were chosen and randomly divided into two groups. The experimental group included 30 cases which were treated with rhEGF and Plaquenil. The other were in the control group treated with Plaquenil only. All the cases were treated for 3 months and had the subsequent visit after 3-month drug withdrawal The curative effects of the two groups were evaluated according to Level 3 curative standard and then compared. Results The total effective rates of experimental group and control group were 93.3％and 33.3% in three months（P<0.05）, 91.23％ and 73.63％ were the effective rates of subsequent visit after three months（P<0.05）.Conclusion The rhEGF with Plaquenil shows better therapeutic response compared with Plaquenilin in subjects with oral lichen planus.

中图分类号:

R781.5

陈蕙萍陈月来. 外用重组人表皮生长因子联合硫酸羟氯喹片治疗糜烂型口腔扁平苔藓的疗效观察[J]. , 2017, 37(7): 632-634.

Hui-Ping CHENG. Efficacy observation of rhEGF with hydroxychloroquine tablets in treating erosive oral lichen planus[J]. , 2017, 37(7): 632-634.

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