›› 2017, Vol. 37 ›› Issue (7): 651-655.

• 综述 • 上一篇    下一篇

成纤维细胞生长因子的研究进展及口腔应用前景

王慧慧1,赵玉梅2   

  1. 1. 同济大学附属口腔医院
    2. 同济大学口腔医学院
  • 收稿日期:2016-12-13 修回日期:2016-12-31 出版日期:2017-07-28 发布日期:2017-07-18
  • 通讯作者: 赵玉梅 E-mail:yumeizhao@tongji.edu.cn

The Progress and Application Prospects in Oral Medicine of Fibroblast Growth Factors

Hui-Hui WANG1,   

  • Received:2016-12-13 Revised:2016-12-31 Online:2017-07-28 Published:2017-07-18

摘要: 摘要:成纤维细胞生长因子(fibroblast growth factors,FGFs)在多种生理和发育过程中发挥着至关重要的作用,它与细胞的生长,增殖,分化,迁移紧密相关。人类和啮齿类动物的成纤维细胞生长因子基因家族中包括22个成员(FGF1-23,其中人类FGF15和鼠FGF19尚未明确),国内外的研究表明成纤维细胞生长因子参与胚胎发育、器官形成、组织修复、新陈代谢、肿瘤形成等多种过程中。但在多种成纤维细胞因子中,关于FGF11的报道相对较少。本综述详细介绍了FGFs的作用机制、生物学功能及研究进展,概括了FGF11的作用,并展望了FGFs在口腔医学研究方面的应用前景。

关键词: 关键词:牙齿发育, FGFs研究进展, FGF11

Abstract: ABSTRACT: Fibroblast growth factors (FGFs) were closely related with cell growth,proliferation, differentiation and migration, which play a key role in multiple developmental and physiological processes. The mammalian FGF gene family consist of 22 members (FGF1-23), human FGF15 and rats FGF19 haven't been identified. Most studies have shown that FGFs involved in the progress of embryonic development, organ formation, tissue repair, metabolism and tumor formation, however, there were less researches on FGF11. This review aims to summarize the mechanism, biological functions and research progress of FGFs, and describe the function of

Key words: KEY WORDS: Tooth development, Research progress of FGFs, FGF11

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