OPN和MMP-3在口腔鳞癌组织中的表达及意义

摘要/Abstract

摘要： 目的　研究骨桥蛋白（OPN）、基质金属蛋白酶-3（MMP-3）在口腔鳞癌组织中的表达、临床意义及相关性。方法　采用免疫组化法检测60例口腔鳞癌组织、30例正常口腔黏膜组织中OPN、MMP-3的表达情况，分析病理特征及相关性。结果　(1)口腔鳞癌组织中OPN及MMP-3阳性表达率分别为68.0%和75.0%，与正常口腔黏膜组相比较差异有统计学意义(P＜0.05)；(2)OPN及MMP-3在口腔鳞癌中的表达与颈淋巴结转移程度、肿瘤分化程度、临床分期有关（P＜0.05）；（3）口腔鳞癌组织中OPN及MMP-3的表达呈正相关，且Spearman相关系数=0. 269(P＜0.05)。结论　OPN、MMP-3 在口腔鳞癌中均高表达，与口腔鳞癌的发生、发展密切相关，且在口腔鳞癌的发生、发展过程中它们的高表达具有协同作用，有可能为口腔鳞癌的早期诊断、判断预后以及靶向治疗提供依据。

关键词: 口腔鳞癌, OPN(骨桥蛋白), MMP-3(基质金属蛋白酶-3), 免疫组化

Abstract: Objective　To investigate the expression of OPN (osteopontin) and MMP-3 (matrix metalloproteinase-3) in oral squamous cell carcinoma and their clinical significance and relevance .Methods The immune- unohistochemical method was performed to detect the expression of OPN and MMP-3 in 60 cases of oral squamous cell carcinoma(OSCC) and 30 cases of normal oral mucosal tissues. The relationship between OPN and MMP-3 and clinicopathological parameters of OSCC was analyzed. Results (1)The positive expression rates of OPN and MMP-3 in oral squamous cell carcinoma tissues were 68.0% and 75.0% respectively. The expressions of OPN and MMP-9 in the oral squamous cell carcinoma and the normal groups had statistically significant difference(P＜0.05).(2)The expression rates of OPN and MMP-3 were correlated with clinical stage, histological differentiation and lymph nodes metastasis (P＜0.05).(3)The expressions of OPN and mmp-3 in oral squamous cell carcinoma were positively correlated, and the correlation index of Spearman was 0.269 (P＜0.05). Conclusion OPN and mmp-3 have high expression in oral squamous cell carcinoma, which is closely related to the occurrence and development of oral squamous carcinoma. Their high expression has synergistic effect on the occurrence and development of oral squamous carcinoma, and it is possible to provide basis for early diagnosis, prognosis and targeted therapy for oral squamous carcinoma.

Key words: oral squamous carcinoma, OPN(osteopontin), MMP-3 (matrix metalloproteinase-3), immuneohistochemical

张玲敏王海侠侯捷赵严礼毛立民. OPN和MMP-3在口腔鳞癌组织中的表达及意义[J]. , 2018, 38(10): 898-902.

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