KLF-6在口腔扁平苔藓恶变中的表达研究

›› 2018, Vol. 38 ›› Issue (2): 132-134.

KLF-6在口腔扁平苔藓恶变中的表达研究

康媛媛¹,张英¹,钟鸣²

1. 中国医科大学口腔医学院
2. 中国医科大学附属口腔医院中心实验室

收稿日期:2016-11-03 修回日期:2017-01-14 出版日期:2018-02-28 发布日期:2018-02-07
通讯作者: 康媛媛 E-mail:kyandly@sina.com

Expression of KLF-6 in the patients with oral lichen planus canceration

Received:2016-11-03 Revised:2017-01-14 Online:2018-02-28 Published:2018-02-07

摘要/Abstract

摘要： 目的探讨KLF6在口腔扁平苔藓发病机制及癌变中的作用。方法分别采用免疫组化和Westernblot方法对10例正常口腔黏膜、30例扁平苔藓患者和22例口腔鳞癌患者的上皮组织中KLF6蛋白进行t检测，比较其在三者之间的差异。SPSS 14.0对数据进行检验。结果扁平苔藓患者组织中KLF6蛋白的表达明显低于正常口腔黏膜，两组之间具有显著性差异；口腔鳞癌患者组织中KLF6蛋白的表达明显低于扁平苔藓组织，两组之间具有显著性差异。结论 KLF6的表达异常可能在口腔扁平苔藓的发生发展及癌变的过程中起作用。

关键词: 扁平苔藓, 鳞癌, 正常口腔黏膜

Abstract: Objective To examine the function of KLF6 in the oral lichen planus pathogenesis and canceration. Methods Immunohistochemistry and Westernblot were used to examine KLF6 protein in 10 cases of normal oral mucosa, 30 cases with oral lichen planus and 22 cases with squamous cell carcinoma. SPSS 14.0 software package was used for t test. Results The expression level of KLF6 protein in 30 cases with oral lichen planus was lower than that in 10 cases with normal oral mucosa and there was significant difference between the two groups(P<0.05).The expression level of KLF6 protein in 22 cases with squamous cell carcinoma was lower than that in 30 cases with oral lichen planus.(P<0.05) and the two groups had significant difference. Conclusions The abnormal expression of KLF6 may play a role in the development and carcinogenesis of OLP.

Key words: oral lichen planus, squamous cell carcinoma, normal oral mucosa

中图分类号:

R781.5

康媛媛张英钟鸣. KLF-6在口腔扁平苔藓恶变中的表达研究[J]. , 2018, 38(2): 132-134.

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