细胞膜片技术及其在种植体表面的应用进展

摘要/Abstract

摘要： 为了提高种植体骨结合，增加种植治疗的成功率，细胞膜片技术从生物学的角度提供了种植体表面改性的新方法。细胞膜片技术是一种保留细胞外基质、不含支架的细胞处理方法，与常规植入材料相结合可形成膜片-种植体复合体。同时越来越多的研究表明细胞膜片可以作为基因工程的载体，搭载成骨相关基因，从而促进种植体骨结合。然而，此项技术在种植体应用方面还面临着一些问题，如膜片种植体制备方法单一、体内膜片种植体存活状况未知等。因此，该文将从细胞膜片及膜片种植体的制备方法、体内细胞膜片的追踪方法等方面对其进行总结。

关键词: 细胞膜片技术, 种植体, 表面改性

Abstract: In order to improve the implant osseointegration and increase success rates of implant treatments, cell sheet technology provides a new method for surface modifications of implants from the perspective of biology. As a cell processing method capable of retaining extracellular matrix, with no scaffolds, the cell sheet can be combined with conventional implant materials to form cell sheetimplant complexes. Moreover, more and more studies have shown that the cell sheet can be used as a genetic engineering carrier to promote implant osseointegration through carrying with related osteogenic genes. However, this technique also has some problems in the application of implants, such as single fabrication method of the complexes and the unknown viability of the complexes in vivo. Therefore, this paper summarized the fabrication methods of the cell sheet and cell sheetimplant complexes, and tracking approaches of the cell sheet in vivo.

Key words: cell sheet technology, implant, surface modification

中图分类号:

R782.1

於科姜治伟杨国利. 细胞膜片技术及其在种植体表面的应用进展[J]. , 2018, 38(2): 172-176.

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