关键词: 自体牙移植, 动物模型, 大鼠

Abstract: Objective　To establish a standardized rat model of autotransplantation of teeth and to analyze its advantages and disadvantages. Methods Five-week-old SD rats were extracted for left upper third molar and second molar firstly. Then, the left upper second molar tooth socket was prepared until it could hold the third molar. After the transplantation, the direction and bite were adjusted. Finally, the fixation was done through resin adhesive. Postoperative oral healing, imaging and histological examination were detected. Results Rats were eligible for autologous tooth transplantation surgery. After 8 weeks, the mouth of the transplanted teeth was still well-fixed, and there was no swelling in the soft tissue. Tissue HE staining showed that the donor teeth and alveolar bone were initially healed. CT scan showed that there was a small amount of bone formation. It had the advantages of short test period, low cost, good repeatability, and acceptable variety of inspection and detection. The shortcomings included: the individual was small, the experimental operation space was small, the degree of refinement was higher, and some operation could not be carried out completely or could not be completed. Conclusion The rats can be used as a standardized animal model of autotransplantation of teeth.

Key words: autogenous tooth transplantation, model animal, rats