CCR6-CCL20轴在口腔扁平苔藓黏膜组织中的表达及意义

›› 2018, Vol. 38 ›› Issue (5): 406-409.

CCR6-CCL20轴在口腔扁平苔藓黏膜组织中的表达及意义

李姗,朱丹丹,范媛

江苏省口腔医院

收稿日期:2017-11-21 修回日期:2018-01-08 出版日期:2018-05-28 发布日期:2018-05-23
通讯作者: 范媛 E-mail:fanyuan@njmu.edu.cn
基金资助:
国家自然科学基金;江苏高校优势学科建设工程资助项目

CCR6 -CCL20 expression profile in peripheral blood and tissue of Oral Lichen Planus

Received:2017-11-21 Revised:2018-01-08 Online:2018-05-28 Published:2018-05-23

摘要/Abstract

摘要： ［摘要］目的检测口腔扁平苔藓(oral lichen planus,OLP)黏膜及正常口腔黏膜中趋化因子CCL20（CC-chemokine ligand 20,CCL20）及其受体CCR6(CC-chemokine receptor 6,CCR6)的表达，研究CCR6-CCL20轴在口腔扁平苔藓病中的作用。方法通过免疫组织化学及荧光定量PCR分别检测口腔扁平苔藓病损组织及正常口腔组织中CCR6和CCL20的蛋白及mRNA的表达。结果 CCR6及CCL20在口腔扁平苔藓患者的黏膜组织中的表达均明显高于正常人，且具有统计学差异(P<0.000 1)。结论 CCR6-CCL20轴参与了口腔扁平苔藓的发生和发展，促进黏膜病损的产生及炎症细胞的浸润。

关键词: 口腔扁平苔藓, CCR6, CCL20

Abstract: Abstract： Objective This study was undertaken to detect variation of CCR6-CCL20 expression in tissue from OLP patients and healthy controls. Methods Real-time quantitative PCR was used to detect the mRNA expression of CCR6 and CCL20 in oral mucosal tissue and immunohistochemistry was used for the detection and localization of CCR6 and CCL20. Results Tissue from OLP patients had markedly up-regulated levels of CCR6 and CCL20 mRNA compared to healthy tissue (P < 0.001). Moreover, immunohistochemical staining showed that in OLP patients, CCR6 and CCL20 expression was obviously higher than that in the control patients. Conclusion The CCR6CCL20 axis may play a role in the immunological mechanism of OLP. [Key words] oral lichen planus; CCR6; CCL20

Key words: oral lichen planus, CCR6, CCL20

中图分类号:

R781.5

李姗朱丹丹范媛. CCR6-CCL20轴在口腔扁平苔藓黏膜组织中的表达及意义[J]. , 2018, 38(5): 406-409.

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