Abstract: Guided bone regeneration (GBR) has some application disadvantages, including poor resistance to resorption and collapse of absorbable barrier membranes, suboptimal bone regeneration due to a second surgical procedure to remove the non-resorbable membrane and the frequent occurrence of membrane exposure to the oral cavity, and the displacement of bone substitute particles and loss of the contour in the augmented site during the placement of membrane. Especially in non-space-maintaining defects, GBR always shows the unpredictability of regenerative capacity because conventional bone substitute materials are only osteoconductive and not osteoinductive scaffolds, and the barrier membrane can’t maintain a stable space for bone regeneration due to unfavorable defect morphologies. Autogenous block grafting may exhibit significant advantages over GBR using particulate substitutes with regard to bone regenerative capacity and biomechanical properties. Even in non-space-maintaining defects, it can provide the osteogenic cells that are necessary for the remodelling and formation of new bone, ideal contour reconstruction and optimal resistance to micromovement and resorption. The conclusion of our standpoint is that GBR is not superior to autogenous grafting in long-term stability of grafted bone.