聚乳酸-羟基乙酸在骨组织工程支架材料中的应用

摘要/Abstract

摘要： 因外伤、肿瘤等多种原因造成的骨组织缺损需要良好的骨组织替代物修复。随着骨组织工程的不断发展，为骨缺损的修复带来了新思路。学者们一直致力于研发与改性各种骨组织工程支架材料以更好地帮助修复骨缺损。聚乳酸-羟基乙酸因具有良好的生物降解性、生物相容性等优点而备受关注。本文仅对近年来在骨组织工程中聚乳酸-羟基乙酸支架材料的改性与设计进行简要综述。

关键词: 聚乳酸-羟基乙酸, 骨组织工程, 支架材料, 骨再生

Abstract: Bone defect caused by trauma, tumor or other causes needs suitable substitute bones to repair. With the development of bone tissue engineering, new ideas are brought to the repair of bone defect. Scientists have been making efforts in developing and optimizing all sorts of scaffold materials for bone tissue engineering to better help repair bone defects. Poly(lactic-co-glycolic acid) has attracted much attention because of its good biodegradability, biocompatibility and other advantages. This paper focuses on reviewing recent studies on design and modification of poly(lactic-co-glycolic acid）scaffold materials in bone tissue engineering.

Key words: poly(lactic-co-glycolic acid), bone tissue engineering, scaffold, bone regeneration

中图分类号:

R782.4

刘璐黄天意史金先王晓容. 聚乳酸-羟基乙酸在骨组织工程支架材料中的应用[J]. , 2019, 39(2): 167-170.

参考文献

[1]Ortegaoller I, Padialmolina M, Galindomoreno P, et al.Bone Regeneration from PLGA Micro-Nanoparticles[J].Biomed Res Int, 2015, 2015(1):1-6 [2]Okamoto M, John B.Synthetic biopolymer nanocomposites for tissue engineering scaffolds[J].Prog Polym Sci, 2013, 38(10-11):1487-1503 [3]Li X, Wang L, Fan Y, et al.Nanostructured scaffolds for bone tissue engineering[J].J Biomed Mater Res A, 2013, 101A(8):2424-2435 [4]Cordonnier T, Sohier J, Rosset P, et al.Biomimetic Materials for Bone Tissue Engineering – State of the Art and Future Trends[J].Adv Eng Mater, 2011, 13(5):B135-B150 [5]Dhandayuthapani B, Yoshida Y, Maekawa T, et al.Polymeric Scaffolds in Tissue Engineering Application: A Review[J].Int J Ploym Sci, 2011, 2011(1687-9422):609-618 [6]Bohner M.Resorbable biomaterials as bone graft substitutes[J].Mater Today, 2010, 13(1-2):24-30 [7]Gentile P, Chiono V, Carmagnola I, et al.An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering[J].Int J Mol Sci, 2014, 15(3):3640-3659 [8] Yuan Y, Shi X, Gan Z, et al.Modification of porous PLGA microspheres by poly-l-lysine for use as tissue engineering scaffolds.[J].Colloids Surf B Biointerfaces, 2017, 161(1):162-168 [9]Shim JH, Moon TS, Yun MJ, et al.Stimulation of healing within a rabbit calvarial defect by a PCLPLGA scaffold blended with TCP using solid freeform fabrication technology[J].J Mater Sci-Mater M, 2012, 23(12):2993-3002 [10]Shuai C, Yang B, Peng S, et al.Development of composite porous scaffolds based on poly(lactide-co-glycolide)nano-hydroxyapatite via selective laser sintering[J].Int J Adv Manuf Tech, 2013, 69(1-4):51-57 [11]Li D, Sun H, Jiang L, et al.Enhanced biocompatibility of PLGA nanofibers with gelatinnano-hydroxyapatite bone biomimetics incorporation[J].Acs Appl Mater Inter, 2014, 6(12):9402-10 [12]Luo Y, Shen H, Fang Y, et al.Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly(lactic-co-glycolic acid) nanofibrous mats[J].Acs Appl Mater Inter, 2015, 7(11):6331-6339 [13]Kim SM, Kim HM, Kuk H, et al.Characterization and Effect of Inflammatory Reaction of Duck-Feet Derived CollagenPoly(lactic-co glycolide)(PLGA) Hybrid Scaffold[J].Polym Korea, 2015, 39(6):837-845 [14] Song JE, Tripathy N, Shin JH, et al.In vivo, bone regeneration evaluation of duck’s feet collagen/PLGA scaffolds in rat calvarial defect.[J].Macromolecular Research, 2017, 25(10):1-6 [15]Hild N, Tawakoli PN, Halter JG, et al.pH-dependent antibacterial effects on oral microorganisms through pure PLGA implants and composites with nanosized bioactive glass[J].Acta Biomater, 2013, 9(11):9118-9125 [16] Haaparanta AM, Uppstu P, Hannula M, et al.Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering[J]. Mat Sci & Eng C, 2015, 56:457.[J].Materials Science & Engineering C, 2015, 56(1):457-466 [17]Li M, Liu W, Sun J, et al.Culturing primary human osteoblasts on electrospun poly(lactic-co-glycolic acid) and poly(lactic-co-glycolic acid)nanohydroxyapatite scaffolds for bone tissue engineering[J].Acs Appl Mater Inter, 2013, 5(13):5921-5926 [18]Igwe JC, Mikael PE, Nukavarapu SP.Design,fabrication and in vitro,evaluation of a novel polymer-hydrogel hybrid scaffold for bone tissue engineering[J].J Tissue Eng & Regen M, 2014, 8(2):131-42 [19]Meng ZX, Li HF, Sun ZZ, et al.Fabrication of mineralized electrospun PLGA and PLGAgelatin nanofibers and their potential in bone tissue engineering[J].Mat Sci & Eng C, 2013, 33(2):699-706 [20]Chen G, Xia Y, Lu X, et al.Effects of surface functionalization of PLGA membranes for guided bone regeneration on proliferation and behavior of osteoblasts[J].J Biomed Mater Res A, 2013, 101A(1):44-53 [21]Ko E, Yang K, Shin J, et al.Polydopamine-Assisted Osteoinductive Peptide Immobilization of Polymer Scaffolds for Enhanced Bone Regeneration by Human Adipose-Derived Stem Cells[J].Biomacromolecules, 2013, 14(9):3202-3213 [22] Kim SE, Yun YP, Shim KS, et al.Effect of lactoferrin-impregnated porous poly(lactide-co-glycolide) (PLGA) microspheres on osteogenic differentiation of rabbit adipose-derived stem cells (rADSCs).[J].Colloids & Surfaces B Biointerfaces, 2014, 122(1):457-464 [23]Zhou P, Cheng X, Xia Y, et al.OrganicInorganic Composite Membranes Based on Poly(l-lactic-co-glycolic acid) and Mesoporous Silica for Effective Bone Tissue Engineering[J].Acs Appl Mater Inter, 2014, 6(23):20895-903 [24] Fu C, Yang X, Tan S, et al.Enhancing Cell Proliferation and Osteogenic Differentiation of MC3T3-E1 Pre-osteoblasts by BMP-2 Delivery in Graphene Oxide-Incorporated PLGA/HA Biodegradable Microcarriers.[J].Scientific Reports , 2017, 7(1):- [25] Caridade S, Mano J.Engineering membranes for bone regeneration.[J].Tissue Engineering Part A, 2017, 23(23-24):1502-1533 [26]Kim I G, Hwang MP, Du P, et al.Bioactive cell-derived matrices combined with polymer mesh scaffold for osteogenesis and bone healing[J].Biomaterials, 2015, 50(1):75-86 [27]Li W, Zheng Y, Zhao X, et al.Osteoinductive Effects of Free and Immobilized Bone Forming Peptide-1 on Human Adipose-Derived Stem Cells[J].Plos One, 2016, 11(3):e0150294- [28]Liu YS, Ou M E, Liu H, et al.The effect of simvastatin on chemotactic capability of SDF-1α and the promotion of bone regeneration[J].Biomaterials, 2014, 35(15):4489-4498 [29]Farokhi M, Mottaghitalab F, Ai J, et al.Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silkcalcium phosphatePLGA based nanocomposite scaffold[J].Int J Pharm, 2013, 454(1):216-225 [30]Farokhi M, Mottaghitalab F, Shokrgozar M A, et al.Bio-hybrid silk fibroincalcium phosphatePLGA nanocomposite scaffold to control the delivery of vascular endothelial growth factor[J].Mat Sci & Eng C, 2014, 35(1):401-410 [31] Quinlan E, López-Noriega A, Thompson E, et al.Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering..[J].Journal of Controlled Release, 2015, 198:71-79 [32] Stevanovi? M, Filipovi? N, Djurdjevi? J, et al.45S5Bioglass(?)-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity.[J].Colloids & Surfaces B Biointerfaces, 2015, 132:208-215 [33] Nazemi K, Azadpour P, Moztarzadeh F, et al.Tissue-engineered chitosan/bioactive glass bone scaffolds integrated with PLGA nanoparticles: A therapeutic design for on-demand drug delivery.[J].Materials Letters, 2015, 138(1):16-20