壳聚糖载药系统及其在骨组织工程中的应用

摘要/Abstract

摘要： 甲壳素作为天然高分子物质在自然界中含量仅次于纤维素，其经脱乙酰化反应后所得的产物壳聚糖，是唯一的天然碱性多糖。壳聚糖具有良好的生物相容性和生物可降解性。以壳聚糖为基质的载药体系具有提高药物生物利用度、改变给药方式和控制释放等优点。本文总结了基于壳聚糖的载药体系的研究进展及其在骨组织工程的应用，并总结所存在的问题和发展前景。

关键词: 壳聚糖, 药物载体, 骨组织工程

Abstract: Chitin is the second most abundant natural resource after cellulose. Chitosan is the product of of the deacylation reaction of chitin. It is the unique cationic polysaccharide in the nature which excellent properties of biocompatibility and biodegradability. The drug delivery systems based on chitosan are proved to be in favor of improving the drug bioavailability , changing its delivery mode and controlling drug release. This review summarizes the research progress of chitosan-based drug delivery systems and its applications in bone tissue engineering.

Key words: chitosan, drug delivery, bone tissue engineering

刘扬吴珺华. 壳聚糖载药系统及其在骨组织工程中的应用[J]. , 2019, 39(4): 354-359.

Yang LIU. The chitosan drug delivery system and its application in bone tissue engineering[J]. , 2019, 39(4): 354-359.

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