拔牙止血方法研究现况综述

摘要/Abstract

摘要： 拔牙后出血是术中及术后极其常见的并发症之一。随着当今三高（高血压、高血脂、高血糖）等各种慢性系统性疾病的高发以及发病人群的低龄化，拔牙后出血发病率逐年增加，且常导致患者生理及心理各种不良后果，尤其伴随“牙医恐惧症”渐被关注，减少甚至避免拔牙出血的方法很有研究价值。本文搜索了CNKI内，1990年-2017年的相关文献，拟用关键词“拔牙”“止血”“并发症”等，经筛选后62篇纳入整理归纳。根据近30年来有关中西医各类拔牙止血方法的机制、利弊及临床疗效的研究作综述,旨在为未来临床新的拔牙止血方法提供科学依据。

关键词: 拔牙术, 止血, 并发症, 常用方法

Abstract: 　Bleeding after tooth extraction is one of the most common complications during and after operation. With the “three high” (high blood pressure, high blood fat, high blood sugar) and other chronic systemic disease incidence and the incidence of a younger age, the incidence of bleeding after tooth extraction is increasing year by year, and often results in various physiological and psychological consequences, especially with the "dental phobia" is attracting attention, to reduce or avoid the extraction method of bleeding has great research value. In this paper, the relevant literature of CNKI during 1990-2017 was researched, and the keywords "tooth extraction", "hemostasis", "complications" and so on were used. After screening, 62 articles were included in the collation and induction. In this paper, the mechanism, advantages and disadvantages and clinical efficacy of various methods of tooth extraction and hemostasis in traditional Chinese and Western medicine in recent 30 years are reviewed. The purpose is to provide a scientific basis for the new method of tooth extraction and hemostasis in the future.

Key words: Tooth extraction, Hemostasis, Complication, Common methods

中图分类号:

　R782.1

赵子慕姜瑶吴雨郑胜汪淑华. 拔牙止血方法研究现况综述[J]. , 2019, 39(4): 380-384.

参考文献 57

[1]	朱国喜.拔牙术后出血原因临床分析[J].现代诊断与治疗, 2013, 24(20):4729-4729
[2]	王友华.220例拔牙术后出血的临床分析[J]. 医学信息, 2013(16): 173-174.
[3]	李秀丽, 王一平.拔牙后出血原因及治疗措施探讨分析[J].中国实用医药, 2012, 7(24):138-139
[4]	廖永青.拔牙术后出血例临床分析[J].青海医药杂志, 2015, 45(3):27-28
[5]	Anand KP, Patro S, Mohapatra A, et al.The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study[J].J Clin Diagn Res, 2015, 9(9):Z-C25
[6]	邱蔚六.口腔颌面外科学[M]. 北京:人民卫生出版社, 2003.
[7]	张志愿.口腔颌面外科学[M]. 北京:人民卫生出版社, 2012:1-614.
[8]	黄晓菲, 杨成.例拔牙术后出血原因和防治的临床分析[J].临床急诊杂志, 2011, 12(6):401-403
[9]	Jain A, Muthusekhar M R, Narayan V, et al.Comparative study of the anesthetic efficacy of 4% articaine versus 2% lignocaine in the inferior alveolar nerve block during the surgical extraction of impacted mandibular third molars[J].Universal Research Journal of Dentistry, 2014, 4(2):108-
[10]	李鹏.拔牙术后感染和皮下气肿的原因与防治体会[J].世界临床医学, 2016, 10(8):197-
[11]	Kim IY, Eichel L, Edwards R, et al.Effects of commonly used hemostatic agents on the porcine collecting system[J].J Endourol, 2007, 21(6):652-654
[12]	周忠笑, 魏晰麟, 姚建茹, 等.生物止血敷料及纱布在外科伤口中的应用评价[J].中国组织工程研究与临床康复, 2010, 14(51):9635-9638
[13]	零月丽.例拔牙创遗留棉球的探讨[J].中国医药指南, 2013, 11(4):513-
[14]	冯刚丽.无偿献血中种按压止血方法的效果比较[J].中国输血杂志, 2012, 25(1):42-
[15]	唐彦峰, 陈建霖, 周云彪.明胶海绵复合生长因子加速颌骨骨折愈合的实验研究[J].华西口腔医学杂志, 2017, 35(5):506-509
[16]	辛香玉.可吸收性止血材料在甲状腺手术中的应用[J]. 医药卫生:全文版, 2016(2):00016-00016.
[17]	刘伟, 劳日初, 黄永泰, 等.吸收性生物止血材料应用于普通外科手术的临床观察[J].中国医药科学, 2015, 5(8):205-207
[18]	Blinder D, Manor Y, Martinowitz U, et al.Dental extractions in patients maintained on continued oral anticoagulant: comparison of local hemostatic modalities[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1999, 88(2):137-140
[19]	张玉成, 钱智勇, 郭希民综述, 等.拔牙术后常用的填塞止血材料[J].武警医学, 2014, 25(12):1280-1282
[20]	温浩, 陈启龙.止血材料在普通外科的应用[J].中国实用外科杂志, 2006, 26(1):33-35
[21]	Ibrahim MF, Aps C, Young CP.A foreign body reaction to Surgicel mimicking an abscess following cardiac surgery[J].Eur J Cardiothorac Surg, 2002, 22(3):489-490
[22]	张丽铃, 何淑琴, 邓志华.纤维蛋白胶的临床应用进展[J].实用医药杂志, 2014, 31(5):451-452
[23]	李征.纤维蛋白胶的作用原理和临床应用及不良反应[J].华西药学杂志, 1999, 14(1):34-36
[24]	黄昌盛, 代文兵, 张强.纤维蛋白胶用于药物递送的研究进展[J].中国药学杂志, 2017, 52(1):8-13
[25]	Gosk J, Knakiewicz M, Wiacek R, et al.The use of the fibrin glue in the peripheral nerves reconstructions[J].Polim Med, 2006, 36(2):11-15
[26]	Yu MS, Kang SH, Kim BH, et al.Effect of aerosolized fibrin sealant on hemostasis and wound healing after endoscopic sinus surgery: a prospective randomized study[J].Am J Rhinol Allergy, 2014, 28(4):335-340
[27]	Cocero N, Pucci F, Messina M, et al.Autologous plasma rich in growth factors in the prevention of severe bleeding after teeth extractions in patients with bleeding disorders: a controlled comparison with fibrin glue[J].Trasfusione del sangue, 2015, 13(2):287-294
[28]	Rodriguez-Merchan EC.Fibrin glue for local haemostasis in haemophilia surgery[J].Hosp Pract, 2017, 45(5):187-191
[29]	Pippi R, Santoro M, Cafolla A.The Use of a Chitosan-Derived Hemostatic Agent for Postextraction Bleeding Control in Patients on Antiplatelet Treatment[J].J Oral Maxillofac Surg, 2017, 75(6):1118-1123
[30]	李伟, 赵国廷, 何秀英.壳聚糖用于拔牙后止血的临床研究[J].血栓与止血学, 2013, 19(5):216-217
[31]	陈斌, 马玲.微创及壳聚糖在阻生齿拔除中的应用效果[J].继续医学教育, 2017, 31(6):89-91
[32]	胡芮.羧甲基壳聚糖锌促进创伤愈合作用的研究[D]. 中国海洋大学, 2015.
[33]	Haaparanta AM, J?rvinen E, Cengiz IF, et al.Preparation and characterization of collagenPLA,chitosanPLA,and collagenchitosanPLA hybrid scaffolds for cartilage tissue engineering[J].J Mater Sci Mater Med, 2014, 25(4):1129-1136
[34]	Smirnou D, Krcmar M, Prochazkova E.Chitin-glucan complex production by Schizophyllum commune submerged cultivation[J].Pol J Microbiol, 2011, 60(3):223-228
[35]	张玉成, 张欣然, 刘翠, 等.超吸水海绵应用于喂服华法林大鼠拔牙创模型的止血效果[J].武警医学, 2015, 26(8):768-770
[36]	李芳芳, 乔朋艳, 董利民, 等.固化中海藻酸钙凝胶微球对细胞的保护及相关影响因素[J].北京大学学报医学版, 2013, 45(1):33-39
[37]	钟诚.复合枸杞多糖的海藻酸钙凝胶微球修复小鼠脊髓损伤的实验研究[D]. 暨南大学, 2016.
[38]	蓝广芊.壳聚糖/明胶复合止血材料的研制及其性能研究[D]. 西南大学, 2016.
[39]	吴祭民, 潘青青, 顾菁菁, 等.改性复合海绵敷料的研制①②[J]. 科技创新导报, 2014(16): 198-199, 201.
[40]	Lan G, Lu B, Wang T, et al.Chitosan/gelatin composite sponge is an absorbable surgical hemostatic agent[J]. Colloids Surf B Biointerfaces, 2015, 136: 1026-1034.
[41]	何谷, 陈煜, 张明明, 等.聚乙烯醇壳聚糖互穿聚合物海绵的制备及应用探索[J].高分子材料科学与工程, 2011, 27(1):150-153
[42]	苏晓迪, 丁克毅, 刘军.聚乙烯醇壳聚糖互穿网络水凝胶的制备及溶胀性能研究[J].西南民族大学学报自然科学版, 2015, 41(2):186-191
[43]	唐力军, 高毅, 赵子粼, 等.碘仿在体内及体外的抑菌作用[J].南方医科大学学报, 2003, 23(11):1207-1210
[44]	陈凯, 王玉栋, 马映霞, 等.碘仿明胶海绵预防下颌水平阻生牙拔除术后并发症的临床观察[J].中国医学创新, 2016, 13(14):93-95
[45]	景蔚.碘仿等预防下颌阻生第三磨牙拔牙术后干槽症的临床观察[J].医药论坛杂志, 2014, 35(5):97-98
[46]	Wu X, Dubick MA, Schwacha MG, et al.Tranexamic Acid Attenuates The Loss of Lung Barrier Function in a Rat Model of Polytrauma And Hemorrhage With Resuscitation[J].Shock, 2017, 47(4):500-505
[47]	张庆, 卢晓栋, 富学禹, 等.全髋关节置换术局部应用氨甲环酸有效性及安全性分析[J].中国中西医结合外科杂志, 2017, 23(1):21-25
[48]	Simmons J, Sikorski RA, Pittet JF.Tranexamic acid: from trauma to routine perioperative use[J].Curr Opin Anaesthesiol, 2015, 28(2):191-200
[49]	Anand KP, Patro S, Mohapatra A, et al.The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study[J].J Clin Diagn Res, 2015, 9(9):Z-C25
[50]	李钒, 田丰, 刘长军, 等.急救止血材料的研究进展[J].材料导报, 2013, 27(3):70-73
[51]	王慧丽, 张瑞.中药疮疡灵可溶性明胶海绵预防干槽症临床研究[J].中医学报, 2011, 26(9):1122-1123
[52]	李玉霞, 苏杰, 田玉平, 等.自制中药“止血粉”治疗拔牙后出血[J].吉林中医药, 2000, 20(6):43-
[53]	卞雅芬, 朱雪尔.珍七散治疗拔牙后出血例[J].浙江中医杂志, 2001, 36(11):477-
[54]	董传清.止血消炎丸例临床疗效观察[J].河南中医, 1992, 12(2):87-
[55]	李冰梅, 王.应用紫草拔牙止血栓处理拔牙创口例疗效观察[J].哈尔滨医药, 1992, 12(3):27-
[56]	Yokozawa T, Oura H, Sakanaka S, et al.Depressor Effect of Tannin in Green Tea on Rats with Renal Hypertension[J].Bioscience, Biotechnology, and Biochemistry, 1994, 58(5):855-858
[57]	Soltani R, Haghighat A, Fanaei M, et al.Evaluation of the effect of green tea extract on the prevention of gingival bleeding after posterior mandibular teeth extraction: a randomized controlled trial[J]. Evid Based Complement Alternat Med, 2014, 2014: 857651.