miRNA-21促进干细胞血管向分化的研究进展

摘要/Abstract

摘要： [摘要] MicroRNAs(miRNAs)是一类真核生物内源性非编码单链RNA，通常为18-22nt长，以完全或非完全互补的方式与其靶mRNA相结合，调节mRNA的表达，从而影响其生物学特征。其作用机制已成为生物医学的主要研究领域，对不同病理类型的检测和治疗具有重要意义。miRNAs在血管系统中含量丰富，尤其是miRNA-21在干细胞血管向分化过程中发挥重要的调控作用，可能是血管系统疾病的重要介质。为此该文就miRNA-21对干细胞血管向分化的影响及机制作一综述。

关键词: miRNA-21, 干细胞, 血管向分化

Abstract: MicroRNAs(miRNAs) are endogenous non-coding single-stranded RNAs of 18-22nt in eukaryotic organisms, which are combined with their target mRNAs in complete or incomplete complementary way and affect their biology characteristics by negatively regulating the expression of mRNAs. The mechanisms of miRNAs have become the main research fields of biomedicine and they play a major role in detection and treatment of different pathological types. miRNAs are abundant in the vascular system, especially miRNA-21 plays an important role in promoting angiogenesis differentiation of stem cells and may be the important mediators in diseases of vascular system. In this paper, the effect and mechanism of miRNA-21 in promoting angiogenesis differentiation of stem cells was overviewed.

Key words: miRNA-21, Stem cells , angiogenesis differentiation of stem cells

中图分类号:

R329.2

褚壮壮汤春波. miRNA-21促进干细胞血管向分化的研究进展[J]. , 2019, 39(5): 446-449.

参考文献

[]Tutar Y. miRNA and cancer; computational and experimental approaches.[J]. Current Pharmaceutical Biotechnology, 2014, 15(5).
[]Ciui, Jambrec D, Sandulescu R, et al. Bioelectrochemistry for miRNA detection[J]. Current Opinion in Therapeutic Patents, 2017,1(5):183-192
[]Vidigal J A, Ventura A. The biological functions of miRNAs: lessons from in vivo studies[J]. Trends in Cell Biology, 2015, 25(3):137
[]吴涛. miR-21促进脐带血间充质干细胞血管向分化作用的初步研究[D]. 安徽医科大学, 2016.
[]Sun Q, Hang M, Guo X, et al. Expression and significance of miRNA-21 and BTG2 in lung cancer.[J]. Tumor Biology, 2013, 34(6):4017-4026.
[]郑金绚, 吴莉萍. 微小RNA21与干细胞之间的关系[J]. 国际口腔医学杂志, 2014, 41(6):716-719.
[] Naito M, Katayama R, Ishioka T, et al. Regulation and function of miRNA-21 in health and disease.[J]. Rna Biology, 2011, 8(5):706-713.
[]Zhou Y J, Feng Y, Chen T, et al. An updated view on the differentiation of stem cells into endothelial cells[J]. Science China Life Sciences, 2014, 57(8):763-773.
[]Hu Y, Deng F, Song J, et al. Evaluation of miR-29c inhibits endotheliocyte migration and angiogenesis of human endothelial cells by suppressing the insulin like growth factor 1.[J]. American Journal of Translational Research, 2015, 7(3):489-501.
[]翁春华, 董豪杰. 靶向调控血管生成素miRNA的筛选和验证[J]. 中国生物化学与分子生物学报, 2015, 31(12):1302-1308.
[]Suárez Y, Sessa W C. microRNAs as novel regulators of angiogenesis[J]. Circulation Research, 2009, 104(4):442-454.
[]Richart A, Loyer X, Néri T, et al. MicroRNA-21 coordinates human multipotent cardiovascular progenitors therapeutic potential.[J]. Stem Cells, 2015, 32(11):2908-2922..
[]田忠奎, 刘琳, 陈冬雷,等. miR-21促进脐带血间充质干细胞血管向分化的体外研究[J]. 上海口腔医学, 2017, 26(5):471-475.
[]Caporali A, Emanueli C. MicroRNA regulation in angiogenesis[J]. Vascular Pharmacology, 2011, 55(4):79.
[]Hu H, Li Y, Gu J, et al. Antisense oligonucleotide against miR-21 inhibits migration and induces apoptosis in leukemic K562 cells[J]. Leukemia & Lymphoma, 2010, 51(4):694.
[]Wang M, Li W, Chang G Q, et al. MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities[J]. Arteriosclerosis Thrombosis & Vascular Biology, 2011, 31(9):2044.
[]Luo Z, Wen G, Wang G, et al. MicroRNA‐200C and ‐150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1[J]. Stem Cells, 2013, 31(9):1749-1762.
[]Voellenkle C, Jv R, Guffanti A, et al. Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs.[J]. Rna-a Publication of the Rna Society, 2012, 18(3):472-484.
[]Singh S K, Kagalwala M N, Parkerthornburg J, et al. REST maintains self-renewal and pluripotency of embryonic stem cells.[J]. Nature, 2008, 453(7192):223.
[]Zhu S, Deng S, Ma Q, et al. MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2[J]. Circulation Research, 2013, 112(1):152-64.
[]Di B E, Campagnolo P, Margariti A, et al. Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor ?22 (TGF-?22) pathways[J]. Journal of Biological Chemistry, 2014, 289(6):3383-3393.
[]王嫱. miRNA对VEGF介导肿瘤血管生成的调控作用研究进展[J]. 山东医药, 2012, 52(34):91-94.
[]Jiang F S, Tian S S, Lu J J, et al. Cardamonin Regulates miR-21 Expression and Suppresses Angiogenesis Induced by Vascular Endothelial Growth Factor.[J]. Biomed Res Int, 2015, 2015(1):501581.
[]Zhao Y, Xu Y, Luo F, et al. Angiogenesis, mediated by miR-21, is involved arsenite-induced carcinogenesis.[J]. Toxicology Letters, 2013, 223(1):35-41.
[]Sabatel C, Malvaux L, Bovy N, et al. MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells[J]. Plos One, 2011, 6(2):e16979.
[]Liu L Z, Li C, Chen Q, et al. MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression[J]. Plos One, 2011, 6(4):e19139.
[]陈惠军, 杨廷桐. 新生儿缺氧缺血性脑病血清中miRNA-21调控HIF-1α表达及临床意义[J]. 中国儿童保健杂志, 2015, 23(1):32-34.
[]Wang M, Li W, Chang G Q, et al. MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities[J]. Arteriosclerosis Thrombosis & Vascular Biology, 2011, 31(9):2044.
[]Stein J J, Iwuchukwu C, Maier K G, et al. Thrombospondin-1-induced vascular smooth muscle cell migration and proliferation are functionally dependent on microRNA-21.[J]. Surgery, 2014, 155(2):228-233.
[]Hu J, Ni S, Cao Y, et al. The Angiogenic Effect of microRNA-21 Targeting TIMP3 through the Regulation of MMP2 and MMP9[J]. Plos One, 2016, 11(2):e0149537.
[]Motawi T M K, Sadik N A H, Shaker O G, et al. Study of microRNAs-21/221 as potential breast cancer biomarkers in Egyptian women[J]. Gene, 2016, 590(2):210-219.
[]姜训圳, 赵科, 何向辉. miRNA-21、miRNA-135b、miRNA-141在结肠癌中的表达及其意义[J]. 中国普通外科杂志, 2014, 23(10):1367-1372.
[]杨寿娟, 张颖, 刘寅. 冠心病患者外周血中miRNA-21的表达水平及其临床意义[J]. 中国应用生理学杂志, 2015, 31(2):127-131.

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