PI3K/AKT通路介导口腔鳞状细胞癌发生发展相关因素的研究进展

摘要/Abstract

摘要： 口腔癌(oral cancer)是唇或口腔的恶性肿瘤,它是世界上10种最常见的恶性肿瘤之一，90％的口腔癌病例是口腔鳞状细胞癌（oral squamous cell carcinoma,OSCC）。PI3K/AKT信号转导通路作为细胞内重要的信号转导通路之一，与多种恶性肿瘤（包括OSCC）的发生、发展关系密切。本文主要对PI3K/AKT通路介导OSCC发生、发展、转移等相关因素做一综述。

关键词: 口腔鳞状细胞癌, PI3K/AKT通路, mTOR

Abstract: Oral cancer is a malignant tumor of the lips or mouth. It is one of the 10 most common cancers in the world. 90% of oral cancer cases are Oral squamous cell carcinoma (OSCC) . PI3K/AKT signal transduction pathway is one of the important signal transduction pathways in cells, and has close relationship with the occurrence and development of many malignant tumors (including OSCC) . This article mainly reviews the PI3K/AKT pathway mediating the occurrence, development and metastasis of oral squamous cell carcinoma.

Key words: oral squamous cell carcinoma, PI3K/AKT pathway, mTOR

中图分类号:

R739.8

王雨施琳. PI3K/AKT通路介导口腔鳞状细胞癌发生发展相关因素的研究进展[J]. , 2019, 39(6): 552-556.

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