智能水凝胶药物控释系统的研究进展

›› 2020, Vol. 40 ›› Issue (10): 956-959.

智能水凝胶药物控释系统的研究进展

李玉芳¹,刘君瑜²,王翔宇³,肖宇⁴,包崇云⁵

1. 山西医科大学口腔医学院
2. 山西医科大学
3. 山西医科大学口腔医学系、口腔医院、口内教研室
4. 四川大学华西口腔医学院
5. 四川大学口腔疾病研究国家重点实验室

收稿日期:2019-09-30 修回日期:2019-11-20 出版日期:2020-10-28 发布日期:2020-10-28
通讯作者: 刘君瑜 E-mail:ljygl@126.com
基金资助:
山西医科大学口腔医院科研课题;山西省高等学校教学改革创新项目

Research progress of intelligent hydrogel drug controlled release system

Received:2019-09-30 Revised:2019-11-20 Online:2020-10-28 Published:2020-10-28

摘要/Abstract

摘要： ［摘要］智能水凝胶，也被称为环境响应型水凝胶，具有感知外界环境某些信号、刺激变化的能力，这些信号主要包括温度、pH值、生物分子、电、光和压力等。这一类材料特殊的理化性能使其在生物体内药物控释的应用上具有很大的潜力。该文介绍了不同响应类型的智能水凝胶的结构和性质，并对其在药物控释系统中的应用作一综述。

关键词: 水凝胶, 环境响应, 药物释放系统

Abstract: Smart hydrogels, also known as environmental responsive hydrogels, have the ability to sense certain signals and stimuli in the external environment, including temperature, pH value, biomolecules, electricity, light and pressure.The special physical and chemical properties of these materials make them have great potential in the application of controlled release of drugs in vivo.In this artical, the structure and properties of different response types of intelligent hydrogels and their applications in drug controlled release systems are reviewed.

Key words: hydrogel, environmental responsive, drug delivery systems

中图分类号:

R783.1

李玉芳刘君瑜王翔宇肖宇包崇云. 智能水凝胶药物控释系统的研究进展[J]. 口腔医学, 2020, 40(10): 956-959.

参考文献 36

[1]	Ahmed EM.Hydrogel: Preparation,characterization,and applications:A revie-w[J].J Adv Res, 2015, 6(2):105-121
[2]	Sood N, Bhardwaj A, Mehta S, et al.Stimuli-responsive hydrogels in drug de-livery and tissue engineering[J].Drug Deliv, 2016, 23(3):758-780
[3]	Wu J, Su ZG, Ma GH.A thermo- and pH-sensitive hydrogel composed of q-uaternized chitosanglycerophosphate[J].Int J Pharm, 2006, 315(1-2):1-11
[4]	Ge J, Neofytou E, Cahill TJ, et al.Drug release from electric-field-responsive nanoparticles[J].ACS Nano, 2012, 6(1):227-233
[5]	Furth ME, Atala A, Van Dyke ME.Smart biomaterials design for tissue engi-neering and regenerative medicine[J].Biomaterials, 2007, 28(34):5068-5073
[6]	Reddy RM, Srivastava A, Kumar A.Monosaccharide-responsive phenylborona-te-polyol cell scaffolds for cell sheet and tissue engineering applications[J].PLoS One, 2013, 8(10):e77861-
[7]	Yuan H, Li B, Liang K, et al.Regulating drug release from pH- and tempera-ture-responsive electrospun CTS-g-PNIPAAmpoly(ethylene oxide) hydrogel nanofibers[J].Biomed Mater, 2014, 9(5):055001-
[8]	Yang J, van Lith R, Baler K, et al.A thermoresponsive biodegradable polym with intrinsic antioxidant properties[J].Biomacromolecules, 2014, 15(11):3942-3952
[9]	Zhang JT, Bhat R, Jandt KD.Temperature-sensitive PVAPNIPAAm semi-I-PN hydrogels with enhanced responsive properties[J].Acta Biomater, 2009, 5(1):488-497
[10]	Cao M, Wang Y, Hu X, et al.Reversible Thermoresponsive PeptidePNIPAM Hydrogels for Controlled Drug Delivery[J].Biomacromolecules, 2019, 20(9):3601-3610
[11]	Trong LC, Djabourov M, Ponton A.Mechanisms of micellization and rheol-ogy of PEO-PPO-PEO triblock copolymers with various architectures[J].J Colloid Interface Sci, 2008, 328(2):278-287
[12]	Fusco S, Borzacchiello A, Netti PA.Perspectives on: PEO-PPOPEO triblo-ck copolymers and their biomedical applications[J]. J Bioact Comp Polym, 2006, 21:149-164.[J].J Bioact Comp Polym, 2006, 21:149-164
[13]	Li J, Pan H, Qiao S, et al.The utilization of low molecular weight heparinp-oloxamer associated Laponite nanoplatform for safe and efficient tumor therapy[J]. Int J Biol Macromol, 2019, 134:63-72.[J].Int J Biol Macromol, 2019, 134:63-72
[14]	Yang R, Sabharwal V, Okonkwo OS, et al.Treatment of otitis media by tran-stympanic delivery of antibiotics[J].Sci Transl Med, 2016, 8(356):356-r
[15]	Mc Gann MJ, Higginbotham CL, Geever LM, et al.The synthesis of novel pH-sensitive poly(vinyl alcohol) composite hydrogels using a freezethaw process for biomedical applications[J].Int J Pharm, 2009, 372(1-2):154-161
[16]	Koetting MC, Peters JT, Steichen SD, et al.Stimulus-responsive hydrogels: T-heory, modern advances, and applications[J]. Mater Sci Eng R Rep, 2015, 93:1-49.[J].Mater Sci Eng R Rep, 2015, 93:1-49
[17]	Gao X, Cao Y, Song X, et al.Biodegradable,pH-responsive carboxymethyl ce-llulosepoly(acrylic acid) hydrogels for oral insulin delivery[J].Macromol Biosci, 2014, 14(4):565-575
[18]	El-Mahrouk GM, Aboul-Einien MH, Makhlouf Al.Design,Optimization,and Evaluation of a Novel Metronidazole-Loaded Gastro-Retentive pH-Sensitive Hydrogel[J].AAPS PharmSciTech, 2016, 17(6):1285-1297
[19]	Rwei SP, Anh THN, Chiang WY, et al.Synthesis and Drug Delivery Applic-ation of Thermo- and pH-Sensitive Hydrogels:Poly(β-CD-co-N-Isopropylacr-ylamide-co-IAM)[J]. Materials(Basel), 2016, 9(12).[J].Materials(Basel), 2016, 9(12):-
[20]	Yue Z, Chen Y, Jin Z, et al.A facile method to fabricate thermo- and pH-s-ensitive hydrogels with good mechanical performance based on poly(ethyle-ne glycol) methyl ether methacrylate and acrylic acid as a potential drug carriers[J].J Biomater Sci Polym Ed, 2019, 30(15):1375-1398
[21]	Zeng X, Li X, Xing L, et al.Electrodeposition of chitosan-ionic liquid-gluco-se oxidase biocomposite onto nano-gold electrode for amperometric glucose sensing[J].Biosens Bioelectron, 2009, 24(9):2898-2903
[22]	Li X, Fu M, Wu J, et al.pH-sensitive peptide hydrogel for glucose-responsiv-e insulin delivery[J]. Acta Biomater, 2017, 51:294-303.[J].Acta Biomater, 2017, 51:294-303
[23]	Liu J, Xiao Y, Wang X, et al.Glucose-sensitive delivery of metronidazole by using a photo-crosslinked chitosan hydrogel film to inhibit Porphyromonas gingivalis proliferation[J]. Int J Biol Macromol, 2019, 122:19-28.[J].Int J Biol Macromol, 2019, 122:19-28
[24]	Tanna S, Sahota T, Clark J, et al.Covalent coupling of concanavalin A to a Carbopol 934P and 941P carrier in glucose-sensitive gels for delivery of insulin[J].J Pharm Pharmacol, 2002, 54(11):1461-1469
[25]	Siegel RA, Gu Y, Lei M, et al.Hard and soft micro- and nanofabrication: An integrated approach to hydrogel-based biosensing and drug delivery[J].J Control Release, 2010, 141(3):303-313
[26]	Zhao F, Wu D, Yao D, et al.An injectable particle-hydrogel hybrid system for glucose-regulatory insulin delivery[J]. Acta Biomater, 2017, 64:334-345.[J].Acta Biomater, 2017, 64:334-345
[27]	Pauly AC, Scholler K, Baumann L, et al.ATRP-based synthesis and characte-rization of light-responsive coatings for transdermal delivery systems[J].Sci Technol Adv Mater, 2015, 16(3):034604-
[28]	Wang C, Zhang G, Liu G, et al.Photo and thermo-responsive multicompart-ment hydrogels for synergistic delivery of gemcitabine and doxorubicin[J]. J Control Release, 2017, 259:149-159.[J].J Control Release, 2017, 259:149-159
[29]	Gao Y, Xu SM, Wu RL, et al.Preparation and characteristic of electric stim-uli responsive hydrogel composed of polyvinyl alcohol/poly(sodium maleate-co- sodium acrylate)[J]. J Appl Polym Sci, 2008, 107:391-395.[J].J Appl Polym Sci, 2008, 107:391-395
[30]	Ali AEH, El-Rehim HAA, Hegazy ESA, et al.Synthesis and electrical response of acrylic acid/vinyl sulfonic acid hydrogels prepared by γ-irradiati-on[J]. Radiat Phys Chem, 2006, 75:1041-1046.[J].Radiat Phys Chem, 2006, 75:1041-1046
[31]	Shang J, Shao Z, Chen X.Electrical Behavior of a Natural Polyelectrolyte Hydrogel:ChitosanCarboxymethylcellulose Hydrogel[J].Biomacromolecules, 2008, 9(4):1208-1213
[32]	Malay O, Bat?gün A, Bayraktar O.pH- and electro-responsive characteristics of silk fibroin–hyaluronic acid polyelectrolyte complex membranes[J].Int J Pharma, 2009, 380(1-2):120-126
[33]	Ge J, Neofytou E, Cahill TJ, et al.Drug release from electric-field-responsive Nanoparticles[J].ACS Nano, 2012, 6(1):227-233
[34]	Qu J, Liang Y, Shi M, et al.Biocompatible conductive hydrogels based on dextran and aniline trimer as electro-responsive drug delivery system for l-ocalized drug release[J]. Int J Biol Macromol, 2019, 140:255-264.[J].Int J Biol Macromol, 2019, 140:255-264
[35]	Song J, He W, Shen H, et al.Self-assembly of a magnetic DNA hydrogel as a new biomaterial for enzyme encapsulation with enhanced activity and stability[J].Chem Commun(Camb), 2019, 55(17):2449-2452
[36]	Kim SJ, Yoon SG, Lee YM, et al.Electrical behavior of polymer hydrogel composed of poly(vinyl alcohol)-hyaluronic acid in solution[J].Biosens Bi-oelectron, 2004, 19(6):531-536