纳米银颗粒用于牙周和种植体周抗菌研究进展

摘要/Abstract

摘要： 菌斑控制是牙周治疗的核心。菌斑控制的效果关乎牙周炎及种植体周围炎治疗的成功与否。对于炎症较重者以及牙周手术或种植手术术后常需辅助应用抗生素。但抗生素存在易诱导抗生素抵抗、对菌斑生物膜中的微生物效率低等缺点。近些年，纳米银颗粒凭借其优良的抗菌性能和不易诱导抵抗的特点，在牙周炎及种植体周围炎的治疗或感染预防中展现出良好的应用前景。该文将综述纳米银颗粒作为潜在抗菌剂用于治疗牙周炎和种植体周围炎的研究进展，主要包括纳米银颗粒的抗菌机制及影响因素、细胞毒性、在牙周炎和在种植体周围炎中的应用潜能四个方面。

关键词: 牙周炎, 种植体周围炎, 纳米银颗粒, 抗菌, 细胞毒性

Abstract: Plaque control is the central tenet of periodontal therapy. The efficacy of plaque control largely determines the prognosis of periodontitis and peri-implantitis. To enhance the effectiveness, antibiotics are usually applied adjunctively to treat severe periodontitis or prevent infection after periodontal surgery and implantation. However, antibiotics application is restricted by the induction of antibiotic resistance and their low efficiency to kill bacteria in the biofilm. Recently, due to the excellent antibacterial properties and less tendency to induce resistance, silver nanoparticles have been explored as an alternative antibacterial agent and are promising to treat periodontitis and peri-implantitis or prevent infection. Therefore, this review has focused on the advances of silver nanoparticles as potential antibacterial agents for periodontal treatment, including the antibacterial mechanism and its influential factors, cytotoxicity, the potential application in periodontitis and peri-implantitis.

Key words: periodontitis, peri-implantitis, silver nanoparticles, antibacterial, cytotoxicity

中图分类号:

R781.4

梁晔邵金龙葛少华. 纳米银颗粒用于牙周和种植体周抗菌研究进展[J]. 口腔医学, 2020, 40(12): 1116-1123.

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