iRoot生物陶瓷材料性能及其在牙髓病学中的应用研究

摘要/Abstract

摘要： iRoot生物陶瓷材料是新兴的以硅钙为基础的生物陶瓷材料，包括iRoot BP Plus、iRoot BP、iRoot SP、iRoot FS等多种剂型。相较于MTA，其具有随取随用、操作性能好，不使牙齿变色等优点，在临床中具有广泛的应用前景。本文针对iRoot BP Plus、iRoot BP组成、性能、及其在牙髓治疗中的应用研究做一综述。

关键词: 生物陶瓷, iRoot BP, iRoot BP Plus, 牙髓治疗

Abstract: iRoot bioceramic materials are emerging silicon-calcium-based bioceramic materials, including iRoot BP Plus, iRoot BP, iRoot SP, iRoot FS and many other dosage forms. Compared with MTA, it has the advantages of easy access, good performance, no discoloration of teeth, and has wide application prospects in clinical practice. This article reviews iRoot BP Plus, iRoot BP composition, performance, and its application in endodontic treatment.

Key words: Bioceramic, iRoot BP, iRoot BP Plus, endodontic treatment

中图分类号:

R781.05

刘燕彭楚芳. iRoot生物陶瓷材料性能及其在牙髓病学中的应用研究[J]. 口腔医学, 2020, 40(4): 376-380.

参考文献 58

[1]	Zhu L, Yang J, Zhang J, et al. In vitro and in vivo evaluation of a nanoparticulate bioceramic paste for dental pulp repair. Acta Biomater. 2014;10(12):5156-68.
[2]	Damas BA, Wheater MA, Bringas JS, et al. Cytotoxicity comparison of mineral trioxide aggregates and EndoSequence bioceramic root repair materials. Journal of Endodontics. 2011.37, 372–5
[3]	Lovato KF，Sedgley CM. Antibacterial activity of EndoSequence root repair material and proroot MTA against clinical isolates of Enterococcus faecalis［J］. J Endod，2011，37（11）：1542-1546.
[4]	Jiang Y, Zheng Q, Zhou X, et al. A comparative study on root canal repair materials: a cytocompatibility assessment in L929 and MG63 cells. Scientific World Journal. 2014, 463826
[5]	Leal F，DeDeus G，Brand?o C，et al. Similar sealability between bioceramic putty ready-to-use repair cement and white MTA［J］. Braz Dent J，2013，24（4）：362-366
[6]	董颖韬,田福聪,贾斌等.凝固时间对生物活性盖髓材料表面粘接强度的影响[J].北京大学学报(医学版),2018,50(01):58-62.
[7]	Caronna V，Himel V，Yu Q，et al. Comparison of the Surface hardness among 3 materials used in an experimental apexification model under moist and dry environments［J］. J Endod，2014，40（7）：986?989.
[8]	Shokouhinejad N, Razmi H, Khoshkhounejad M, Javani A, Raoof M. Surface microhardness of different thicknesses of a premixed bioceramic material with or without the application of a moist cotton pellet. Dental research journal. 2016;13(1):58-62.。
[9]	Lee YL, Lee BS, Lin FH, et al. Effects of physiological environments on the hydration behavior of mineral trioxide aggregate. Biomaterials. 2004;25:787–93.
[10]	Deepthi V, Mallikarjun E, Nagesh B, Mandava P. Effect of acidic pH on microhardness and microstructure of theraCal LC, endosequence, mineral trioxide aggregate, and biodentine when used as root repair material. Journal of conservative dentistry : JCD. 2018;21(4):408-12.。
[11]	Wang Z，Ma J，Shen Y，et al. Acidic pH weakens the microhard?ness and microstructure of three tricalcium silicate materials［J］. Int Endod J，2015，48（4）：323?332
[12]	Walsh RM，Woodmansey KF，Glickman GN，et al. Evaluation of compressive strength of hydraulic silicate?based root?end filling materials［J］. J Endod，2014，40（7）：969?972.
[13]	Nair U，Ghattas S，Saber M，et al. A comparative evaluation of the sealing ability of 2 root -end filling materials：an in vitro leakage study using Enterococcus faecalis［J］. Oral Surg Oral Med Oral Pathol Oral Radiol Endod，2011，112（2）：e74-e77.
[14]	Onay EO，Gogos C，Ungor M，et al. Effect of Er，Cr：YSGG laser irradiation on apical sealing ability of calcium silicatecontaining endodontic materials in root?end cavities［J］. Dent Mater J，2014，33（4）：570?575.
[15]	Hirschberg CS，Patel NS，Patel LM，et al. Comparison of sealing ability of MTA and EndoSequence Bioceramic Root Repair Material：a bacterial leakage study［J］. Quintessence Int，2013，44（5）：e157-e162.
[16]	Jeevani E, Jayaprakash T, Bolla N, et al. Evaluation of sealing ability of MM-MTA, Endosequence, and biodentine as furcation repair materials: UV spectrophotometric analysis. J Conserv Dent. 2014;17(4):340–43.
[17]	王密,尹世海,王奇等. iRoot BP修复磨牙髓室底穿孔的研究[J].华西口腔医学杂志,2013,31(03):257-259+266.
[18]	谢克贤,黎远皋,张平等.酸蚀处理对根尖倒充填材料封闭性的影响[J].北京大学学报(医学版),2018,50(01):69-72.
[19]	Shokouhinejad N，Yazdi KA，Nekoofar MH，et al. Effect of acidic environment on dislocation resistance of EndoSequence root repair material and mineral trioxide aggregate［J］. J Dent（Tehran），2014，11（2）：161?166.
[20]	Shokouhinejad N，Razmi H，Nekoofar MH，et al. Push-out bond strength of bioceramic materials in a synthetic tissue fluid［J］. J Dent （Tehran）, 2013，10（6）：540?547.
[21]	Kazem Ashofteh Yazdi, a Behnam Bolhari, a Tohid Sabetmoghaddam，et.al. Effect of Blood Exposure on Push-Out Bond Strength of Four Calcium Silicate Based Cements. Iran Endod J. 2017 Spring; 12(2): 196–200
[22]	Oncel Torun Z, Torun D, Demirkaya K, et al. Effects of iRoot BP and white mineral trioxide aggregate on cell viability and the expression of genes associated with mineralization. Int Endod J. 2015;48(10):986-93.
[23]	Chen I, Salhab I, Setzer FC, et.al. A New Calcium Silicate-based Bioceramic Material Promotes Human Osteo- and Odontogenic Stem Cell Proliferation and Survival via the Extracellular Signal-regulated Kinase Signaling Pathway. J Endod. 2016;42(3):480-6.
[24]	De-Deus G, Canabarro A, Alves GG, et.al. Cytocompatibility of the ready-to-use bioceramic putty repair cement iRoot BP Plus with primary human osteoblasts. International Endodontic Journal.2012, 45, 508–13.
[25]	Willershausen I, Wolf T, Kasaj A, et al. Influence of a bioceramic root end material and mineral trioxide aggregates on fibroblasts and osteoblasts [J]. A rch Oral Biol, 2013, 58(9 ):1232 -1237
[26]	史爽,包志凡,陈旭等.新型牙髓治疗材料iRoot BP Plus对人牙龈成纤维细胞的细胞毒性[J].上海口腔医学,2014,23(06):681-684
[27]	Ma J, Shen Y, Stojieie S，et.al. Biocompatibility of two novel root repair materials [J]. J Endod,2011,37(6): 793-798
[28]	Miller AA, Takimoto K, Wealleans J, Diogenes A. Effect of 3 Bioceramic Materials on Stem Cells of the Apical Papilla Proliferation and Differentiation Using a Dentin Disk Model. J Endod. 2018;44(4):599-603.
[29]	Tian J, Zhang Y, Lai Z, et al. Ion Release, Microstructural, and Biological Properties of iRoot BP Plus and ProRoot MTA Exposed to an Acidic Environment. J Endod. 2017;43(1):163-8.
[30]	Zhang S, Yang X, Fan M. BioAggregate and iRoot BP Plus optimize the proliferation and mineralization ability of human dental pulp cells. Int Endod J 2013; 46:923–9.
[31]	Torun D, Torun ZO, Demirkaya K, et al. Gene expression changes in bioceramic paste-treated human dental pulp cells. J Oral Sci. 2016;58(3):307-15.
[32]	Zhu LX, Yang J W, Zhang J, et al. In vitro and in vivo evaluation of a nanoparticulate bilceramic paste for dental pu;p repair. [J]. Acta Biomater, 2014, 10 (12): 5156-5168.
[33]	乔迪,董艳梅,高学军.体外评价新型根尖倒充填材料iRoot的生物学性能[J].北京大学学报(医学版),2016,48(02):324-329.
[34]	Zhang J, Zhu LX, Cheng X, et al. Promotion of Dental Pulp Cell Migration and Pulp Repair by a Bioceramic Putty Involving FGFR-mediated Signaling Pathways. J Dent Res. 2015;94(6):853-62.
[35]	Lv F, Zhu L, Zhang J, et al. Evaluation of the in vitro biocompatibility of a new fast-setting ready-to-use root filling and repair material. Int Endod J. 2017;50(6):540-8.
[36]	Alsalleeh F，Chung N，Stephenson L. Antifungal activity of EndoSequence root repair material and mineral trioxide aggregate［J］. J Endod，2014，40（11）：1815?1819.
[37]	Damlar I，Ozcan E，Yula E，et al. Antimicrobial effects of several calcium silicate?based root?end filling materials［J］. Dent Mater J，2014，33（4）：453?457.
[38]	Hansen SW，Marshall JG，Sedgley CM. Comparison of intracanal EndoSequence Root Repair Material and ProRoot MTA to induce pH changes in simulated root resorption defects over 4 weeks in matched pairs of human teeth［J］. J Endod，2011，37（4）：502?506
[39]	Elshamy FM, Singh G, Elraih H, et al. Antibacterial Effect of New Bioceramic Pulp Capping Material on the Main Cariogenic Bacteria. The journal of contemporary dental practice. 2016;17(5):349-53.
[40]	Khalil WA, Abunasef SK. Can Mineral Trioxide Aggregate and Nanoparticulate EndoSequence Root Repair Material Produce Injurious Effects to Rat Subcutaneous Tissues? J Endod. 2015;41(7):1151-6.
[41]	Taha NA, Safadi RA, Alwedaie MS. Biocompatibility Evaluation of EndoSequence Root Repair Paste in the Connective Tissue of Rats. J Endod. 2016;42(10):1523-8.
[42]	Kim S， Chen I， Karabucak B， et al． Healing after root-end microsurgery by using mineral trioxide aggregate and a new calcium silicate-based bioceramic material as root-end filling materials in dogs． J Endod， 2015， 41( 3) : 389-399
[43]	Liu S, Wang S, Dong Y. Evaluation of a bioceramic as a pulp capping agent in vitro and in vivo. J Endod. 2015;41(5):652-7.
[44]	Okamoto M, Takahashi Y, Komichi S, et al. Novel evaluation method of dentin repair by direct pulp capping using high-resolution micro-computed tomography. Clin Oral Investig. 2018;22(8):2879-87.
[45]	Shi S, Bao ZF, Liu Y, et al. Comparison of in vivo dental pulp responses to capping with iRoot BP Plus and mineral trioxide aggregate. Int Endod J. 2016;49(2):154-60.
[46]	梅雪，谢俐萍，金幼虹，等. iRoot BP Plus直接盖髓后比格犬牙髓的反应性变化［J］. 口腔医学研究，2016，32（12）：1234?123
[47]	黄伟曼,张栋杰,胡旭初等.iRoot BP Plus和MTA用于年轻恒牙直接盖髓的临床疗效观察[J].中华口腔医学研究杂志(电子版),2017,11(06):366-370.
[48]	梁秋娟,肖朋,古力巴哈?买买提力.IRoot BP Plus和MTA两种材料用于年轻恒牙活髓切断术的临床比较[J].全科口腔医学电子杂志,2018,5(18):8-9.
[49]	丁美丽,秦满,郑佳佳等.新型生物陶瓷材料用于年轻恒牙牙髓切断术的效果评价[J].口腔医学研究,2018,34(07):766-770.
[50]	Azimi S, Fazlyab M, Sadri D, et al. Comparison of pulp response to mineral trioxide aggregate and a bioceramic paste in partial pulpotomy of sound human premolars: a randomized controlled trial. Int Endod J. 2014;47(9):873-81.
[51]	Michaelson PL, Holland GR. Is pulpitis painful? International Endodontic Journal. 2002, 35, 829–32.
[52]	Jiang S, Wu H, Zhang CF. Partial Pulpotomy of Immature Teeth with Apical Periodontitis using Bioceramics and Mineral Trioxide Aggregate: A Report of Three Cases. Chin J Dent Res. 2016;19(2):115-20
[53]	Zhou W, Zheng Q, Tan X, et al. Comparison of Mineral Trioxide Aggregate and iRoot BP Plus Root Repair Material as Root-end Filling Materials in Endodontic Microsurgery: A Prospective Randomized Controlled Study. J Endod. 2017;43(1):1-6.
[54]	于梦琪,侯本祥.生物陶瓷材料iRoot BP Plus在显微根尖手术中应用的疗效分析[J].北京口腔医学,2016,24(02):87-91.
[55]	von Arx T, Penarrocha M, Jensen S. Prognostic factors in apical surgery with rootend filling: a meta-analysis. J Endod 2010;36:957–73
[56]	刘景,袁媛.生物陶瓷iRoot BP plus和无机三氧化物聚合物在未成年患者根尖孔未闭合患牙形成根尖屏障中的效果对比[J].全科口腔医学电子杂志,2018,5(20):1-2+7.
[57]	Sockalingam S, Awang Talip M, Zakaria ASI. Maturogenesis of an Immature Dens Evaginatus Nonvital Premolar with an Apically Placed Bioceramic Material (EndoSequence Root Repair Material(R)): An Unexpected Finding. Case Rep Dent. 2018;2018:6535480.
[58]	N. Shokouhinejad, M. H. Nekoofar, H. Razmi et al. Bioactivity of EndoSequence Root Repair Material and bioaggregate. International Endodontic Journal, vol. 45, no. 12, pp. 1127–1134, 2012