牙周炎与系统性红斑狼疮相关性研究进展

摘要/Abstract

摘要： 系统性红斑狼疮(SLE)是一种慢性炎症性疾病，被认为是一种典型的自身免疫性疾病。牙周炎是一种牙周组织的慢性感染，可导致全身和局部炎症反应，并通过免疫反应破坏牙周支持组织。两者的临床病理均涉及结缔组织的破坏，发病机制也都涉及T、B细胞的表达和功能异常以及细胞因子的表达紊乱。本文从流行病学表现、免疫、遗传及家族因素、细菌感染、细胞因子等方面对牙周炎和系统性红斑狼疮两者的相关性作一综述。

关键词: ［关键词］　牙周炎, 系统性红斑狼疮, 细胞因子, B细胞活化因子, 青蒿素

Abstract: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that is considered to be a classic autoimmune disease. Periodontitis is chronic infection of periodontal tissue that can lead to systemic and local inflammatory responses and destroy periodontal support tissue through an immune response.The clinicopathology of both involves the destruction of connective tissue, and the pathogenesis also involves the abnormal expression and function of T and B cells as well as the expression disorder of cytokines. This article reviews the relationship between periodontitis and systemic lupus erythematosus from the aspects of epidemiology, immunity, genetic and familial factors, bacterial infection and cytokines.

Key words: Key words：　periodontitis, Systemic Lupus Erythematosus, cytokines, B-cell activating factor, artemisinin

张力木林晓萍. 牙周炎与系统性红斑狼疮相关性研究进展[J]. 口腔医学, 2020, 40(9): 833-838.

Li-Mu ZHANG. Progress in the study of the correlation between periodontitis and systemic lupus erythematosus[J]. Stomatology, 2020, 40(9): 833-838.

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