牙周炎与阿尔茨海默病双向关系研究

摘要/Abstract

摘要： 牙周炎是发生于牙周支持组织的炎症性、感染性疾病，随着牙周医学的发展，牙周炎与阿尔茨海默病的相关性逐渐成为研究热点。阿尔茨海默病是老年人最常见的神经系统退行性变疾病，发病机制较为复杂，已有临床研究发现牙周炎与阿尔茨海默病密切相关。本文就牙周炎与阿尔茨海默病在流行病学、疾病发病机制与疾病治疗上的双向关系进行综述。

关键词: 牙周炎, 阿尔茨海默病, 牙龈卟啉单胞菌, 脂多糖

Abstract: Periodontitis is an inflammatory and infectious disease that occurs in the periodontal support tissue. With the development of periodontal medicine, the correlation between periodontitis and Alzheimer's disease has gradually become a hot topic. Alzheimer's disease is the most common neurological degenerative disease with complicated pathogenesis in the elderly. Clinical studies have found that periodontitis is closely related to Alzheimer's disease. This article will review the two-way relationship between periodontitis and Alzheimer's disease in epidemiology, pathogenesis and treatments.

Key words: Periodontitis, Alzheimer’s disease, P.gingivalis, LPS

沈慧宋忠臣. 牙周炎与阿尔茨海默病双向关系研究[J]. 口腔医学, 2020, 40(9): 839-842.

参考文献

[1]马莉莉，王兴，王渤，等，.8[J].第四次中国口腔健康流行病学调查报人民卫生出版社千字, 2018, 1( 1): - [2]Alzheimer’s Association.Alzheimer’s disease facts and figures[J].Alzheimers Dement, 2016, 12(4):459-509 [3]Maurer K, Rahming S, Prvulovic D.Dental health in advanced age and Alzheimer’s Disease: A possible link with bacterial toxins entering the brain?[J].[J] Psychiatry Res Neuroimaging, 2018, 282(1):132-133 [4]唐毅，.阿尔茨海默病中国负担及非药物治疗，[J].[J]，中国药理学与毒理学杂志，, 2019,, 33(6):403-404 [5]Choi S, Kim K, Chang J, et al.Association of Chronic Periodontitis on Alzheimer’s Disease or Vascular Dementia[J].J Am Geriatr Soc, 2019, 67(6):1234-1239 [6]Renvert S, Persson GR.Treatment of periodontal disease in older adults[J].Periodontol, 2016, 72(1):108-119 [7]Sung CE, Huang RY, Cheng WC, et al.Association between periodontitis and cognitive impairment: Analysis of national health and nutrition examination survey (NHANES) Ⅲ[J].J Clin periodontol, 2019, 46(8):790-798 [8]Ide M, Harris M, Stevens A, et al.Periodontitis and Cognitive Decline in Alzheimer’s Disease[J].PLoS One, 2016, 11(3):1-9 [9]Holmer J, Eriksdotter M, Schultzberg M, et al.Association between periodontitis and risk of Alzheimer's disease,mild cognitive impairment and subjective cognitive decline: A case-control study[J].J Clin Periodontol, 2018, 45(11):1287-1298 [10]Maldonado A, Lauqisch O, Burqin W, et al.Clinical periodontal variables in patients with and without dementia-a systematic review and meta-analysis[J].Clin Oral Investiq, 2018, 22(7):2463-2474 [11]杨宓，柏雪，.365例老年痴呆患者口腔及牙周状况分析[J].[J]，重庆医学, 2018, 47(16):2185-2188 [12]热依拉·居热提，魏奕茹，何攀龙，等.新疆汉维两民族阿尔茨海默病患者的牙周健康状况调查[J].重庆医科大学学报, 2016, 41(12):1267-1271 [13]Hshioka S, Inoue K, Miyaoka T, et al.The possible causal link of periodontitis to neuropsychiatric disorders: More than psychosocial mechanisms.[J].Int. J. Mol. Sci.,, 2019,, 20(15): 3723-3734 [14]D’Mello C, Swain MG.Immune-to-Brain Communication Pathways in Inflammation-Associated Sickness and Depression[J].[J]. Curr Top Behav Neurosci, 2017, 31(4):73-94 [15]Singhrao SK, Olesen I.Are porphyromonas gingivalis outer membrane vesicles microbullets for sporadic Alzheimer’s disease manifestation?[J].J Alzheimers Dis Rep, 2018, 2(1):219-228 [16]Ramseier CA, Anerud A, Dulac M, et al.Natural history of periodontitis: Disease progression and tooth loss over 40 years[J].J Clin Periodontol, 2017, 44(12):1182-1191 [17]McConnell ES, Lee KH, Galkowski L, et al.Improving Oral Hygiene for Veterans With Dementia in Residential Long-term Care[J].[J] J Nurs Care Qual, 2018, 33(3):229-237 [18]Herde AM, Schibli R, Weber M, et al.Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients[J].Eur J Nucl Med Mol Imaging, 2019, 46(2):407-420 [19]Sochocka M, Zwolinska K, Leszek J.The Infectious Etiology of Alzheimer's Disease[J].Curr Neuropharmacol, 2017, 15(7):996-1009 [20]Ilievski V, Zuchowska PK, Green SJ, et al.Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice[J].PLoS one, 2018, 13(10):1-24 [21]Wu, Z., Ni, J., Liu, Y,et al.Cathepsin B plays a critical role in inducing Alzheimer’s disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice.[J].Brain Behavior and Immunity, 2017, 65(1):350-361 [22]Nie R, Wu Z, Ni J, et al.Porphyromonas gingivalis Infection Induces Amyloid-β Accumulation in MonocytesMacrophages[J].J Alzheimers Dis, 2019, 72(2):479-494 [23]Diaz-Zuniga J, Munoz Y, Meglar-Rodringuez S, et al.Serotype b of Aggregatibacter actinomycetemcomitans triggers pro-inflammatory responses and amyloid beta secretion in hippocampal cells: a novel link between periodontitis and Alzheimer′s disease?[J].J Oral Microbiol, 2019, 11(1):1-11 [24]Aarabi G, Thomalla G, Heydecke G, et al.Chronic oral infection: An emerging risk factor of cerebral small vessel disease[J].Oral Dis, 2019, 25(3):710-719 [25]Ng A, Tam WW, Zhang MW, et al.IL-1β,IL-6,TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis[J].Sci Rep, 2018, 8(1):1-12 [26]Magalh?es CA, Ferreira CN, Loures CMG, et al.Leptin, hsCRP, TNF-α and IL-6 levels from normal aging to dementia: Relationship with cognitive and functional status. [J]. J Clin Neurosci, 2018, 56(1):150-155 [27]Laurent C, Buee L, Blum D.Tau and neuroinflammation: What impact for Alzheimer’s Disease and Tauopathies?[J].Biomed J, 2018, 41(1):21-33 [28]Zhou J, Yu M, Zhang M, et al.Imbalance of Microglial TLR4TREM2 in LPS-Treated APPPS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation[J].Neurochem Res, 2019, 44(5):1138-1151 [29]Sabharwal A, Gomes-Filho IS, Stellrecht E, et al.Role of periodontal therapy in management of common complex systemic diseases and conditions: An update[J].Periodontol, 2018, 78(1):212-226 [30]Harding A, Ribinson S, Singhrao SK.Can Better Management of Periodontal Disease Delay the Onset and Progression of Alzheimer's Disease?[J].J Alzheimers Dis, 2017, 58(2):337-348 [31]Gao LB, Yu XF, Chen Q, et al.Alzheimer’s disease therapeutics: current and future therapies[J].Minerva Med, 2016, 107(2):108-113 [32]Muniz FWMG, Melo IM, Rosing CK, et al.Use of antidepressive agents as a possibility in the management of periodontal disease: A systematic review of experimental studies.[J].J Investig Clin Dent, 2018, 9(1):1-6 [33]Naoyuki I, Yuichi I, Kazuto I, et al.Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice.[J]. NPJ Aging Mech Dis, 2017, 3(15):1-7 [34]Fereshtehnejad SM, Garcia-Ptacek S, Religa D, et al.Dental care utilization in patients with different types of dementia: A longitudinal nationwide study of 58,037 individuals[J].Alzheimers Dement, 2018, 14(1):10-19 [35]McConnell ES, Lee KH, Galkowski L, et al.Improving Oral Hygiene for Veterans With Dementia in Residential Long-term Care[J].J Nurs Care Qual, 2017, 33(03):229-237