成牙本质细胞分化信号通路研究进展

摘要/Abstract

摘要： 成牙本质细胞由牙髓干细胞分化而来。大量实验表明，在牙髓干细胞向成牙本质细胞分化过程中多种生物因子可激活Smad、MAPK、WNT、Notch信号通路继而影响成牙本质细胞分化。而成牙本质细胞分化是成牙本质细胞有序排列并形成正常牙本质的重要前提。因此下文就近年来对成牙本质细胞分化信号通路的研究进展进行阐述。

关键词: 成牙本质细胞, Smad, MAPK, WNT, Notch

Abstract: Odontoblasts are differentiated from dental pulp stem cells. A large number of experiments have shown that many kinds of biological factors can activate Smad, MAPK, Wnt, Notch signal pathways which affect the differentiation of odontoblasts. The differentiation of odontoblasts is important for the orderly arrangement odontoblasts and the formation of normal dentin. In this paper, we reviewed the research progress of differentiation signaling pathway of odontoblasts.

Key words: odontoblast, Smad, MAPK, WNT, Notch

中图分类号:

R349.54

田子璐刘艺萍王珏朱松孙宏晨倪世磊. 成牙本质细胞分化信号通路研究进展[J]. 口腔医学, 2020, 40(9): 847-850.

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