Runx2基因表达与正畸牙移动牙周改建

摘要/Abstract

摘要： Runx2是一种成骨分化特异性转录因子，在成骨细胞的形成以及分化、破骨细胞的形成和活化等过程中都发挥着重要的作用。正畸牙移动（orthodontic tooth movement, OTM）是牙齿在受到一定正畸力的作用后，对牙周膜产生压缩或牵张的力，牙周组织发生生理限度内的改建，继而达到牙齿移动的一个过程。不少学者对加速正畸牙移动和维持正畸牙移动效果的方法感兴趣，研究认为Runx2在正畸牙移动过程中牙周改建有重要作用，其基因的表达高低在正畸牙移动牙周改建具有一定的积极作用，本文对该方面相关研究结果进行一个阐述。

关键词: Runx2, 牙移动, 正畸力, 成骨细胞

Abstract: Runx2 is a specific transcription factor of osteogenic differentiation, which plays an important role in the formation and differentiation of osteoblasts, the formation and activation of osteoclasts. Orthodontic tooth movement(OTM) is a process in which teeth compress or stretch the periodontal ligament after being subjected to a certain orthodontic force, and the periodontal tissue is rebuilt within the physiological limit, and then the tooth movement is achieved.Many scholars are interested in the methods of accelerating orthodontic tooth movement and maintaining orthodontic tooth movement. It is considered that Runx2 plays an important role in periodontal remodeling during orthodontic tooth movement, and its gene expression plays a positive role in orthodontic tooth movement periodontal remodeling. In this paper, the related research results are described.

Key words: Runx2, tooth movement, orthodontic force, osteoblasts

中图分类号:

R783.5

邵佳琪张佳男卢海平. Runx2基因表达与正畸牙移动牙周改建[J]. 口腔医学, 2020, 40(9): 851-854.

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