抗菌材料在固定矫治中的应用研究进展

摘要/Abstract

摘要： 固定矫治技术是治疗错牙合畸形的主要方法之一，然而固定矫治器会影响口腔微生态环境，进而可能诱发釉质脱矿、牙龈炎等疾病。将具有抗菌性能的材料应用于正畸粘接剂、弓丝、托槽等固定矫治器的制备，可以为预防上述疾病的发生提供一种新的思路与方法。本文就有机抗菌剂、无机抗菌剂、复合抗菌剂等抗菌材料在固定矫治中的应用的研究进展作一综述。

关键词: ［关键词］　抗菌材料, 固定矫治, 正畸粘接剂, 托槽, 弓丝

Abstract: Abstract：Fixed orthodontic technology is one of the main methods to treat malocclusion. However, the orthodontic appliances may affect the microecological environment of the oral cavity, which may lead to diseases such as enamel demineralization and gingivitis. The application of antibacterial materials in the preparation of fixed orthodontic appliances, such as orthodontic adhesives, arch wires brackets, etc., can provide a new method for preventing these diseases. This paper reviews the application research progress of organic antibacterial agents, inorganic antibacterial agents and other antibacterial materials in fixed orthodontic treatment.

Key words: Key words：　Antibacterial materials, Fixed orthodontic technology, Orthodontic adhesives, Brackets, Arch wires

中图分类号:

R783.5

刘万颖管晓燕周莉肖琳琳龙茜胡欢刘建国. 抗菌材料在固定矫治中的应用研究进展[J]. 口腔医学, 2021, 41(3): 274-278.

参考文献

[1] Papageorgiou S N, Xavier G M, Cobourne M T, et al. Effect of orthodontic treatment on the subgingival microbiota: A systematic review and meta‐analysis[J]. Orthod Craniofac Res, 2018,21(4):175-185.

[2] Arab S, Nouhzadeh M S, Abouei M E, et al. Effect of Fixed Orthodontic Treatment on Salivary Flow, pH and Microbial Count[J]. J Dent, 2016,13(1):18-22.

[3] 刘继明. 氮掺杂二氧化钛涂层复合弓丝的制备及其性能的研究[D]. 吉林大学, 2017.

[4] Hoglund K B, Barnett B K, Watson S A, et al. Activity of bioactive garlic compounds on the oral microbiome: a literature review[J]. Gen Dent, 2020,68(3):27-33.

[5] Yu F, Dong Y, Yu H, et al. Antibacterial Activity and Bonding Ability of an Orthodontic Adhesive Containing the Antibacterial Monomer 2-Methacryloxylethyl Hexadecyl Methyl Ammonium Bromide[J]. Scientific reports, 2017,7(1):41787.

[6] O'Reilly M M, Featherstone J D. Demineralization and remineralization around orthodontic appliances: an in vivo study[J]. Am J Orthod Dentofacial Orthop, 1987,92(1):33-40.

[7] Shashidhar E P, Sahitya M, Sunil T, et al. A Comparative Evaluation of Adherence of Microorganism to Different Types of Brackets: A Scanning Electron Microscopic Study[J]. J Int Oral Health, 2015,7(9):25-30.

[8] Benson P E, Alexander-Abt J, Cotter S, et al. Resin-modified glass ionomer cement vs composite for orthodontic bonding: A multicenter, single-blind, randomized controlled trial[J]. Am J Orthod Dentofacial Orthop, 2019,155(1):10-18.

[9] Imazato S. Antibacterial properties of resin composites and dentin bonding systems[J]. Dent Mater, 2003,19(6):449-457.

[10] Imazato S. Bio-active restorative materials with antibacterial effects: new dimension of innovation in restorative dentistry[J]. Dent Mater J, 2009,28(1):11-19.

[11] 张宁, 张珂, 白玉兴. 抗菌性正畸粘接剂的研究进展[J]. 首都医科大学学报, 2016,37(03):294-298.

[12] Liu Y, Zhang L, Niu L N, et al. Antibacterial and remineralizing orthodontic adhesive containing quaternary ammonium resin monomer and amorphous calcium phosphate nanoparticles[J]. J Dent, 2018,72:53-63.

[13] 谌礼佩, 熊洁, 江青松. 纳米抗菌剂在口腔医学中的研究进展[J]. 口腔颌面修复学杂志, 2019,20(6):351-356.

[14] Ferrando-Magraner E, Bellot-Arcís C, Paredes-Gallardo V, et al. Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis[J]. Medicina, 2020,56(2):55.

[15] 李振霞, 薛晶, 陈婷婷, 等. 纳米二氧化钛对正畸粘接剂抗菌性与拉伸粘接强度的影响[J]. 口腔医学, 2016,36(7):591-594.

[16] Leyland N S, Podporska-Carroll J, Browne J, et al. Highly Efficient F, Cu doped TiO2 anti-bacterial visible light active photocatalytic coatings to combat hospital-acquired infections[J]. Sci Rep, 2016,6:24770.

[17] Chambers C, Stewart S B, Su B, et al. Silver doped titanium dioxide nanoparticles as antimicrobial additives to dental polymers[J]. Dent Mater, 2017,33(3):e115-e123.

[18] 王艳华, 王晓颖. 纳米银改性正畸粘接剂的研究[J]. 中华老年口腔医学杂志, 2016,14(01):6-9.

[19] Yin I X, Zhang J, Zhao I S, et al. The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry[J]. Int J Nanomedicine, 2020,15:2555-2562.

[20] Meikle T G, Dyett B P, Strachan J B, et al. Preparation, Characterization, and Antimicrobial Activity of Cubosome Encapsulated Metal Nanocrystals[J]. ACS Appl Mater Interfaces, 2020,12(6):6944-6954.

[21] 海涵. 季铵盐抗菌剂在口腔材料中的应用现状与发展趋势概述[J]. 全科口腔医学电子杂志, 2019,6(16):7-9.

[22] Zhou H, Li F, Weir M D, et al. Dental plaque microcosm response to bonding agents containing quaternary ammonium methacrylates with different chain lengths and charge densities[J]. J Dent, 2013,41(11):1122-1131.

[23] Wang X, Zhang N, Wang B, et al. Novel self-etching and antibacterial orthodontic adhesive containing dimethylaminohexadecyl methacrylate to inhibit enamel demineralization[J]. Dent Mater J, 2018,37(4):555-561.

[24] Cao L, Xie X, Wang B, et al. Protein-repellent and antibacterial effects of a novel polymethyl methacrylate resin[J]. J Dent, 2018,79:39-45.

[25] 刘?. 新型抗菌再矿化功能性正畸粘接剂的合成和性能研究[D]. 中国人民解放军空军军医大学, 2018.

[26] Dias H B, Bernardi M, Marangoni V S, et al. Synthesis, characterization and application of Ag doped ZnO nanoparticles in a composite resin[J]. Mater Sci Eng C Mater Biol Appl, 2019,96:391-401.

[27] 赵夫健, 王臻石, 石连水. 托槽表面抗菌改性的研究现状[J]. 国际口腔医学杂志, 2016,43(02):239-243.

[28] 刘洪波. 生物医用TiNiCu合金的表面改性及其性能研究[D]. 哈尔滨工程大学, 2018.

[29] Cao S, Wang Y, Cao L, et al. Preparation and antimicrobial assay of ceramic brackets coated with TiO? thin films[J]. Korean Journal of Orthodontics, 2016,46(3):146-154.

[30] Ghasemi T, Arash V, Rabiee S M, et al. Antimicrobial effect, frictional resistance, and surface roughness of stainless steel orthodontic brackets coated with nanofilms of silver and titanium oxide: a preliminary study[J]. Microsc Res Tech, 2017,80(6):599-607.

[31] 王建卫, 王宇, 车远倩, 等. 制备TiO_2-xNx薄膜陶瓷托槽的抗菌性能[J]. 中国组织工程研究, 2016,20(34):5039-5044.

[32] Khorrami S, Zarrabi A, Khaleghi M, et al. Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties[J]. Int J Nanomedicine, 2018,13:8013-8024.

[33] Duran N, Nakazato G, Seabra A B. Antimicrobial activity of biogenic silver nanoparticles, and silver chloride nanoparticles: an overview and comments[J]. Appl Microbiol Biotechnol, 2016,100(15):6555-6570.

[34] Jasso-Ruiz I, Velazquez-Enriquez U, Scougall-Vilchis R J, et al. Synthesis and Characterization of Silver Nanoparticles on Orthodontic Brackets: A New Alternative in the Prevention of White Spots[J]. Coatings, 2019,9(8):480.

[35] Meyer-Kobbe V, Doll K, Stiesch M, et al. Comparison of intraoral biofilm reduction on silver-coated and silver ion-implanted stainless steel bracket material[J]. J Orofac Orthop, 2019,80(1):32-43.

[36] Ghasemi T, Arash V, Rabiee S M, et al. Antimicrobial effect, frictional resistance, and surface roughness of stainless steel orthodontic brackets coated with nanofilms of silver and titanium oxide: a preliminary study[J]. Microsc Res Tech, 2017,80(6):599-607.

[37] Espinosa-Cristóbal L F, López-Ruiz N, Cabada-Tarín D, et al. Antiadherence and Antimicrobial Properties of Silver Nanoparticles against Streptococcus mutans on Brackets and Wires Used for Orthodontic Treatments[J]. Journal of nanomaterials, 2018,2018:1-11.

[38] Sultankulov B, Berillo D, Sultankulova K, et al. Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine[J]. Biomolecules, 2019,9(9).

[39] Shariatinia Z. Carboxymethyl chitosan: Properties and biomedical applications[J]. International Journal of Biological Macromolecules, 2018,120(Pt B):1406-1419.

[40] 谢兵伍, 周建萍, 王雪蔓, 等. 正畸弓丝表面功能化修饰后抗腐蚀及抗菌性的研究[J]. 上海交通大学学报(医学版), 2016,36(04):491-495.

[41] Park S, Kim H, Yang S B, et al. A Polysaccharide-Based Antibacterial Coating with Improved Durability for Clear Overlay Appliances[J]. ACS Appl Mater Interfaces, 2018,10(21):17714-17721.