脂联素在骨代谢中的研究进展

摘要/Abstract

摘要： 上颌窦侧壁开窗提升是增加后牙骨量的有效治疗方式，其成功取决于新骨的形成和植体的长期存活率。影响上颌窦侧壁开窗提升后新骨形成及植体存活率的因素有很多，例如剩余牙槽骨高度、骨窗尺寸、骨窗覆盖方式、植骨方式等。有学者认为减小骨窗面积能保留更多骨壁，而覆盖生物屏障膜或游离骨块能防止软组织侵入，对于新骨生成和提高植体存活率有一定积极作用。有学者提出将具有分化潜能的成体干细胞、生长因子替代自体骨与其他骨替代材料混合应用以促进新骨形成。有学者提出同期种植时剩余牙槽骨高度的降低或不植骨的侧壁开窗提升方式不会影响新骨形成和植体存活率，从而扩大上颌窦侧壁开窗提升的手术适应证。本文就这几个因素展开讨论。

关键词: 脂联素, 脂联素受体, 脂肪细胞因子, 骨代谢

Abstract: Adiponectin (APN) is an endogenous cytokine secreted by adipose tissue. After binding to the receptor, it participates in the body's metabolic regulation. Therefore, adiponectin and adiponectin receptors have also become important molecular targets for the treatment of metabolic diseases. The research of adiponectin signal transduction has a positive effect on guiding the clinical treatment of bone metabolism related diseases. This article reviews the biological characteristics of adiponectin, its signal transduction, and the effects of adiponectin on bone metabolism to provide a reference for the treatment of adiponectin in bone metabolic diseases.

Key words: Adiponectin, Adiponectin receptor, Adipokine, Osteoanabolic

中图分类号:

冯瑶贾婷婷王亚楠张东姣徐欣. 脂联素在骨代谢中的研究进展[J]. 口腔医学, 2021, 41(3): 284-288.

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