适配体的应用及其在口腔领域的研究进展

doi:10.13591/j.cnki.kqyx.2022.04.015

摘要/Abstract

摘要： 适配体是一种与特定RNA或蛋白质等靶向结合的单链DNA或RNA。适配体具有高度特异性、低免疫原性、成本低等特点,已被广泛用于生物医学的各个领域。本文就适配体的筛选、特点以及其在口腔医学领域中疾病诊断、治疗和组织再生的研究进展作一综述,并对其在口腔医学中的应用前景进行展望。

关键词: 适配体, 口腔医学, 诊断与治疗, 靶向递送, 再生

Abstract: Aptamer is a short oligonucleotide sequence (ssDNA or RNA), which can bind to specific target like RNA or protein. It has been widely used in fields of biomedicine with advantages of high specificity, low immunogenicity, low cost and so on. The purpose of this article is to summarize its screening and characteristics and progress of research on aptamer in diagnosis, treatment and tissue regeneration in stomatology. In addition, its application prospect in stomatology is reviewed.

Key words: aptamer, stomatology, diagnosis and treatment, targeted delivery, regeneration

中图分类号:

梁言, 许梓楠, 蔡明详, 刘湘宁. 适配体的应用及其在口腔领域的研究进展[J]. 口腔医学, 2022, 42(4): 358-361.

LIANG Yan, XU Zinan, CAI Mingxiang, LIU Xiangning. Applications and research progress of aptamerin stomatology[J]. Stomatology, 2022, 42(4): 358-361.

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