活化型基质金属蛋白酶-8作为牙周生物标志物的研究进展

doi:10.13591/j.cnki.kqyx.2022.04.018

摘要/Abstract

摘要： 具有高度特异性和稳定性的牙周生物标志物可辅助临床对牙周病分期分级进行更好划分。活化型基质金属蛋白酶-8(aMMP-8)可降解细胞外基质及基底膜,其异常表现与牙周炎的发生发展有着密切联系。本文就aMMP-8在牙周炎中的表达作一综述,旨在探讨aMMP-8成为牙周炎生物标志物的可行性。

关键词: 牙周炎, 活化型基质金属蛋白酶-8, 牙周生物标志物

Abstract: Periodontal biomarkers with high specificity and stability can contribute to classifying periodontal diseases by different stages and grades in clinic. Activated matrix metalloproteinase-8 (aMMP-8) can degrade extracellular matrix and basal lamina. Abnormal expression of aMMP-8 is closely related to the initiation and development of periodontitis. In this paper, we reviewed the expression of aMMP-8 in periodontitis, aiming to explore feasibility of aMMP-8 as a biomarker of periodontitis.

Key words: periodontitis, activated matrix metalloproteinase-8, periodontal biomarker

中图分类号:

R781.4

赵宇琪, 田胜兰, 李莹, 王爱芹. 活化型基质金属蛋白酶-8作为牙周生物标志物的研究进展[J]. 口腔医学, 2022, 42(4): 373-376.

ZHAO Yuqi, TIAN Shenglan, LI Ying, WANG Aiqin. Research progress of activated matrix metalloproteinase-8 as a periodontal biomarker[J]. Stomatology, 2022, 42(4): 373-376.

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