浓缩生长因子联合盐酸米诺环素软膏治疗干槽症疗效研究

doi:10.13591/j.cnki.kqyx.2022.07.009

口腔医学 ›› 2022, Vol. 42 ›› Issue (7): 622-626.doi: 10.13591/j.cnki.kqyx.2022.07.009

浓缩生长因子联合盐酸米诺环素软膏治疗干槽症疗效研究

马廷林, 艾力麦尔旦·艾尼瓦尔, 汝悦, 图玛热·阿里木, 地力努尔·克然木, 苏庆玲, 古丽, 王玲

新疆医科大学第一附属医院(附属口腔医院)颌面外科门诊/新疆维吾尔自治区口腔医学研究所,新疆乌鲁木齐(830000)

修回日期:2022-02-18 出版日期:2022-07-28 发布日期:2022-07-22
通讯作者: 王玲 Tel:(0991)4366402 E-mail:crystalwl272@126.com
基金资助:
新疆维吾尔自治区自然科学基金 (2016D01C250)

Study on the efficacy of concentrated growth factor combined with minocycline hydrochloride ointment in the treatment of dry socket

MA Tinglin, Alimaierdan·ANIWAER, RU Yue, Tumare·ALIMU, Dlinuer·KRANMU, SU Qingling, GU Li, WANG Ling

Outpatient Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Xinjiang Medical University/Xinjiang Uygur Autonomous Region Institution of Stomatology, Urumqi 830000, China

Revised:2022-02-18 Online:2022-07-28 Published:2022-07-22

摘要/Abstract

摘要： 目的评估浓缩生长因子(CGF)联合盐酸米诺环素软膏在缓解疼痛、控制炎症和促进拔牙窝新生肉芽组织方面治疗干槽症的有效性。方法选择2021年3月—9月就诊于新疆医科大学附属口腔医院颌面外科门诊的40例干槽症患者,被随机分配两组,分别为:CGF联合盐酸米诺环素软膏组(A组)20例,碘仿纱条组(B组)20例,研究对比两组不同治疗干槽症方法的临床疗效。在第0、1、4、7、14和21天对患者随访检查,采用视觉模拟评分评估疼痛程度、牙龈指数评估牙龈炎症程度、肉芽组织评估拔牙窝软组织的生长程度。结果与B组相比,A组在缓解疼痛、控制炎症和促进拔牙窝新生肉芽组织生长的效果更好,研究结果差异有统计学意义(P<0.05)。结论 CGF联合盐酸米诺环素软膏治疗干槽症的临床效果良好,值得临床借鉴。

关键词: 干槽症, 浓缩生长因子(CGF), 盐酸米诺环素软膏

Abstract: Objective To evaluate the efficacy of concentrated growth factor (CGF) in combination with minocycline hydrochloride ointment in relieving pain, controlling inflammation, and promoting the growth of new granulation tissue in tooth sockets. Methods A total of 40 patients with dry socket who were admitted to the Maxillofacial Surgery Department of The Affiliated Stomatological Hospital of Xinjiang Medical University from March to September 2021 were randomly assigned to two groups. Twenty cases of CGF combined with minocycline hydrochloride ointment (group A) and 20 cases of iodoform gauze (group B) were used to study and compare the clinical efficacy of two different treatment methods for dry socket. Patients were followed up on day 0, 1, 4, 7, 14, and 21. Visual analogue scale (VAS) was used to evaluate the degree of pain. Gingival index (GI) was used to evaluate the degree of gingival inflammation. Granulation tissue (GT) was used to evaluate the degree of soft tissue growth in tooth socket. Results Compared with group B, group A was more effective in relieving pain, controlling inflammation and promoting the growth of new granulation tissue in tooth socket, and the results were statistically different (P<0.05). Conclusion CGF combined with minocycline hydrochloride ointment has a good clinical effect on the treatment of dry socket, which is worthy of reference in clinical practice.

Key words: dry socket, concentrated growth factor, minocycline hydrochloride ointment

中图分类号:

R782.11

马廷林, 艾力麦尔旦·艾尼瓦尔, 汝悦, 图玛热·阿里木, 地力努尔·克然木, 苏庆玲, 古丽, 王玲. 浓缩生长因子联合盐酸米诺环素软膏治疗干槽症疗效研究[J]. 口腔医学, 2022, 42(7): 622-626.

MA Tinglin, Alimaierdan·ANIWAER, RU Yue, Tumare·ALIMU, Dlinuer·KRANMU, SU Qingling, GU Li, WANG Ling. Study on the efficacy of concentrated growth factor combined with minocycline hydrochloride ointment in the treatment of dry socket[J]. Stomatology, 2022, 42(7): 622-626.

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浓缩生长因子联合盐酸米诺环素软膏治疗干槽症疗效研究

Study on the efficacy of concentrated growth factor combined with minocycline hydrochloride ointment in the treatment of dry socket

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