TACAN参与正畸机械性疼痛调控的研究进展

doi:10.13591/j.cnki.kqyx.2024.07.010

摘要/Abstract

摘要：

正畸治疗主要通过对颌骨以及牙齿施加机械力来改善口腔功能,达到治疗目标。而口腔疼痛则是患者诊疗过程中最常见的症状,它通常由持续施加的正畸机械力引起,但其机制尚未完全明确,是临床上的重要难题。而近年来研究发现了一种蛋白—TACAN,在疼痛发生发展的过程中起到关键的调控作用,有望成为未来治疗机械性疼痛的治疗靶点。由于对TACAN的研究尚不明确,其具体机制还有待进一步阐明和验证,所以本文系统回顾了TACAN参与机械性疼痛调控的研究进展,梳理了TACAN发挥的具体功能,为TACAN的进一步研究提供新的思路。

关键词: TACAN, 口腔机械性疼痛, 离子通道

Abstract:

Orthodontic treatment mainly improves oral function and achieves treatment goals by applying mechanical force to the jawbone and teeth. However, oral pain is the most common symptom experienced by patients during the diagnosis and treatment process. It is usually caused by sustained application of orthodontic mechanical force, but its mechanism is not fully understood, posing a significant clinical challenge. In recent years, a protein called TACAN has been discovered to play a crucial regulatory role in the occurrence and development of pain, offering a potential therapeutic target for addressing mechanical pain in the future. Since research on TACAN is still unclear, its specific mechanism requires further elucidation and verification. This article systematically reviews the research progress of TACAN’s involvement in the modulation of mechanical pain, summarizes the specific functions of TACAN, and provides new perspectives for further research on TACAN.

Key words: TACAN, oral mechanical pain, ion channel

中图分类号:

R783.5

徐思艺, 杨振泽, 薛蕾蕾, 齐叶子, 林军. TACAN参与正畸机械性疼痛调控的研究进展[J]. 口腔医学, 2024, 44(7): 540-544.

XU Siyi, YANG Zhenze, XUE Leilei, QI Yezi, LIN Jun. Research progress of TACAN’s involvement in orthodontic mechanical pain modulation[J]. Stomatology, 2024, 44(7): 540-544.

参考文献 43

[1]	阿迪拉·艾赛提, 王琛, 周薇娜, 等. 颞下颌关节紊乱病患者与健康人群颌面部机械疼痛敏感性的比较[J]. 口腔医学, 2021, 41(4):303-308.
[2]	Tang ZW, Zhou JW, Long H, et al. Molecular mechanism in trigeminal nerve and treatment methods related to orthodontic pain[J]. J Oral Rehabil, 2022, 49(2):125-137.
[3]	吴嵩, 缪伟男, 张雪文, 等. 正畸疼痛的临床研究[J]. 口腔医学, 2018, 38(6):556-559.
[4]	Lai TT, Chiou JY, Lai TC, et al. Perceived pain for orthodontic patients with conventional brackets or self-ligating brackets over 1 month period: A single-center, randomized controlled clinical trial[J]. J Formos Med Assoc, 2020, 119(<W>1 Pt 2):282-289.
[5]	许博洋, 李浩然, 郭义. 基于软骨细胞机械敏感性离子通道力学转导的疼痛机制探讨[J]. 中国疼痛医学杂志, 2021, 27(7):534-539, 544.
[6]	He JZ, Li BT, Han SZ, et al. Drosophila as a model to study the mechanism of nociception[J]. Front Physiol, 2022, 13: 854124.
[7]	杨子圆, 卢海平, 康婷. Piezo1离子通道在口腔医学中的研究进展[J]. 口腔医学, 2020, 40(11):1046-1049.
[8]	Thammanichanon P, Kaewpitak A, Binlateh T, et al. Varied temporal expression patterns of trigeminal TRPA1 and TRPV1 and the neuropeptide CGRP during orthodontic force-induced pain[J]. Arch Oral Biol, 2021, 128: 105170.
[9]	赵逢璐. 施万细胞TRPA1在正畸疼痛中的作用研究[D]. 济南: 山东大学, 2021.
[10]	Malik P, Korfali N, Srsen V, et al. Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope[J]. Cell Mol Life Sci, 2010, 67(8):1353-1369. doi: 10.1007/s00018-010-0257-2 pmid: 20091084
[11]	Schirmer EC, Florens L, Guan TL, et al. Nuclear membrane proteins with potential disease links found by subtractive proteomics[J]. Science, 2003, 301(5638):1380-1382. pmid: 12958361
[12]	Beaulieu-Laroche L. 参与机械痛感知的新型离子通道: TACAN[J]. 中国疼痛医学杂志, 2020, 26(4):247.
[13]	Batrakou DG, de Las Heras JI, Czapiewski R, et al. TMEM120A and B: Nuclear envelope transmembrane proteins important for adipocyte differentiation[J]. PLoS One, 2015, 10(5):e0127712.
[14]	Beaulieu-Laroche L, Christin M, Donoghue A, et al. TACAN is anion channel involved in sensing mechanical pain[J]. Cell, 2020, 180(5):956-967.e17. doi: S0092-8674(20)30114-8 pmid: 32084332
[15]	Arenas OM, Lumpkin EA. Touching base with mechanical pain[J]. Cell, 2020, 180(5):824-826. doi: S0092-8674(20)30166-5 pmid: 32142674
[16]	Rong Y, Jiang JH, Gao YW, et al. TMEM120A contains a specific coenzyme A-binding site and might not mediate poking-or stretch-induced channel activities in cells[J]. eLife, 2021, 10: e71474.
[17]	Xue J, Han Y, Baniasadi H, et al. TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase[J]. eLife, 2021, 10: e71220.
[18]	Chen XZ, Wang YJ, Li Y, et al. Cryo-EM structure of the human TACAN in a closed state[J]. Cell Rep, 2022, 38(9):110445.
[19]	Niu YM, Tao X, Vaisey G, et al. Analysis of the mechanosensor channel functionality of TACAN[J]. eLife, 2021, 10: e71188.
[20]	Jakobsson A, Westerberg R, Jacobsson A. Fatty acid elongases in mammals: Their regulation and roles in metabolism[J]. Prog Lipid Res, 2006, 45(3):237-249. doi: 10.1016/j.plipres.2006.01.004 pmid: 16564093
[21]	Nie LY, Pascoa C, Pike ACW, et al. The structural basis off attyacidelongation by the ELOVL elongases[J]. Nat Struct Mol Biol, 2021, 28(6):512-520.
[22]	de Las Heras JI, Zuleger N, Batrakou DG, et al. Tissue-specific NETs alter genome organization and regulation even in a heterologous system[J]. Nucleus, 2017, 8(1):81-97. doi: 10.1080/19491034.2016.1261230 pmid: 28045568
[23]	Czapiewski R, Batrakou DG, de Las Heras JI, et al. Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy[J]. Nat Commun, 2022, 13(1):321. doi: 10.1038/s41467-021-27869-2 pmid: 35027552
[24]	Qian NC, Li S, Tan X. The curious case of TMEM120A: Mechanosensor, fat regulator, or antiviral defender?[J]. Bioessays, 2022, 44(6):e2200045.
[25]	赵凡迪, 徐辉. 正畸疼痛在牙周牙髓中的分子机制及疼痛控制[J]. 北京口腔医学, 2019, 27(4):236-240.
[26]	Rahman F, Harada F, Saito I, et al. Detection of acid-sensing ion channel 3 (ASIC3) in periodontal Ruffini endings of mouse incisors[J]. Neurosci Lett, 2011, 488(2):173-177. doi: 10.1016/j.neulet.2010.11.023 pmid: 21078372
[27]	Erdinç AM, Dinçer B. Perception of pain during orthodontic treatment with fixed appliances[J]. Eur J Orthod, 2004, 26(1):79-85.
[28]	Pokhilko A, Nash A, Cader MZ. Common transcriptional signatures of neuropathic pain[J]. Pain, 2020, 161(7):1542-1554. doi: 10.1097/j.pain.0000000000001847 pmid: 32107361
[29]	Shang YC, Li YH, Yang ZY, et al. Upregulation of TACAN in the trigeminal ganglion affects pain transduction in acute pulpitis[J]. Arch Oral Biol, 2022, 143: 105530.
[30]	Bonet IJM, Araldi D, Bogen O, et al. Involvement of TACAN, a mechanotransducing ion channel, in inflammatory but not neuropathic hyperalgesia in the rat[J]. J Pain, 2021, 22(5):498-508.
[31]	Zhang XL, Lei Y, Xiao YB, et al. Hen egg lysozyme alleviates static mechanical pain via NRF1-parkin-TACAN signaling axis in sensory neurons[J]. Neuroscience, 2022, 502: 52-67.
[32]	Murthy SE, Dubin AE, Whitwam T, et al. OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels[J]. e Life, 2018, 7: e41844.
[33]	Kefauver JM, Ward AB, Patapoutian A. Discoveries in structure and physiology of mechanically activated ion channels[J]. Nature, 2020, 587(7835):567-576.
[34]	Anderson EO, Schneider ER, Matson JD, et al. TMEM150C/Tentonin3 is a regulator of mechano-gated ion channels[J]. Cell Rep, 2018, 23(3):701-708. doi: S2211-1247(18)30455-8 pmid: 29669276
[35]	Szczot M, Nickolls AR, Lam RM, et al. The form and function of PIEZO2[J]. Annu Rev Biochem, 2021, 90: 507-534. doi: 10.1146/annurev-biochem-081720-023244 pmid: 34153212
[36]	Del Rosario JS, Gabrielle M, Yudin Y, et al. TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels[J]. J Gen Physiol, 2022, 154(8):e202213164.
[37]	Zhang MM, Wang YF, Geng J, et al. Mechanically activated piezo channels mediate touch and suppress acute mechanical pain response in mice[J]. Cell Rep, 2019, 26(6):1419-1431.e4. doi: S2211-1247(19)30085-3 pmid: 30726728
[38]	Liu X, Zhang R, Fatehi M, et al. Regulation of PKD2 channel function by TACAN[J]. J Physiol, 2023, 601(1):83-98.
[39]	Douguet D, Patel A, Honoré E. Structure and function of polycystins: Insights into polycystic kidney disease[J]. Nat Rev Nephrol, 2019, 15(7):412-422. doi: 10.1038/s41581-019-0143-6 pmid: 30948841
[40]	Köttgen M, Buchholz B, Garcia-Gonzalez MA, et al. TRPP2 and TRPV4 form a polymodal sensory channel complex[J]. J Cell Biol, 2008, 182(3):437-447. doi: 10.1083/jcb.200805124 pmid: 18695040
[41]	Kobori T, Smith GD, Sandford R, et al. The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2: 2 stoichiometry and an alternating subunit arrangement[J]. J Biol Chem, 2009, 284(51):35507-35513.
[42]	Peyronnet R, Martins JR, Duprat F, et al. Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells[J]. EMBO Rep, 2013, 14(12):1143-1148. doi: 10.1038/embor.2013.170 pmid: 24157948
[43]	Empitu MA, Kadariswantiningsih IN. Regulation of PKD2 channel by TACAN: How does it link to cystogenesis in autosomal dominant polycystic kidney disease?[J]. J Physiol, 2023, 601(5):887-888.