溶血磷脂酸调控骨改建作用的研究进展

doi:10.13591/j.cnki.kqyx.2024.09.010

摘要/Abstract

摘要：

溶血磷脂酸(lysophosphatidic acid,LPA)是机体内天然存在的一种小分子甘油磷脂。其在人体内分布广泛,与其受体LPA _1-6结合后,经复杂的下游信号转导机制,介导细胞增殖、迁移等多种细胞学行为,进而参与肿瘤发生发展、炎症、创伤愈合等生物学过程。近年来,LPA在调控骨代谢方面的作用受到越来越多的关注。它一方面可以直接作用于骨相关细胞,另一方面可以作为骨组织中神经-血管-免疫-骨的潜在交联因子,为骨改建提供良好的微环境,进一步影响骨再生。该文就溶血磷脂酸调控骨代谢作用的研究进展作一综述。

关键词: 溶血磷脂酸, 骨改建, G蛋白偶联受体

Abstract:

Lysophosphatidic acid (LPA), a simple bioactive lysophospholipid widely dispersed in human body, has been reported to regulate the proliferation, chemotaxis and differentiation of multiple cells and further participate in various developmental and pathophysiological processes through at least six specific G protein-coupled receptors (GPCRs), LPA₁-LPA₆. Recently, the possibility of targeting LPA or LPA receptors in bone remodeling has been heatedly discussed. On the one hand, LPA modulate the activities of bone-related cells directly. On the other hand, LPA might be the potential regulator that links the nervous-vascular-immune-skeletal systems, which could provide a good microenvironment for bone remodeling and further promote bone regeneration. Thus, this review summarizes recent studies on the effects and application prospect of LPA on bone remodeling.

Key words: lysophosphatidic acid, bone remodeling, G-proteincoupledreceptor

中图分类号:

R344.3

张勤, 向琳, 宫苹. 溶血磷脂酸调控骨改建作用的研究进展[J]. 口腔医学, 2024, 44(9): 699-704.

ZHANG Qin, XIANG Lin, GONG Ping. Advances in lysophosphatidic acid for bone remodeling[J]. Stomatology, 2024, 44(9): 699-704.

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