›› 2015, Vol. 35 ›› Issue (12): 1060-1063.
• Investigation and study • Previous Articles Next Articles
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Abstract: Objective To explore the domestic epidemiology characteristics and risk factors of nonsyndromic cleft lip with or without palate,so as to provide basis for for its early prevention.Methods A casecontrol study recruiting nonsyndromic cleft lip with or without palate patients and healthy controls from Jiangsu,Anhui and its surrounding areas was designed.A questionnaire (a total of 14 factors,including family history,parental educational level,childbearing age,pregnancy reaction,parity,drug use during pregnancy,infections,active and passive smoking during pregnancy,alcohol consumption during pregnancy,nutritional status,etc) was investigated and further analyzed by chisquare test and logistic regression analysis.Results 352 nonsyndromic cleft lip with or without palate cases as well as 602 healthy controls were recruited in the final study.Univariate analysis showed pregnant reaction,passive smoking during pregnancy,educational level of the father and family history were associated with nonsyndromic cleft lip with or without palate.These factors together with educational level of mother and vitamin intake were also significant in multivariate analysis.Conclusions Pregnancy reaction,passive smoking during pregnancy,parental educational level,vitamin intake and family history may be related factors of nonsyndromic cleft lip with or without palate in Jiangsu,Anhui and its surrounding areas.
Key words: nonsyndromic cleft lip with or without palate, casecontrol study, risk factors
CLC Number:
R363.1
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http://www.stomatology.cn/EN/Y2015/V35/I12/1060