›› 2015, Vol. 35 ›› Issue (12): 1080-1084.

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The research progress of antibiotictolerance persisters in microorganism community

  

  • Received:2015-06-08 Revised:2015-08-22 Online:2015-12-28 Published:2015-12-15

Abstract: Treated with a fatal dose of antibiotic,most microbial population will soon die,while some subpopulation cannot be eliminated and thus survive.Different from the traditional resistant mutants,these bacterial strains do not change as to their gene sequence.After the collection and reincubation of the bacterial strains,its been found that their minimal inhibitory concentration (MIC) remains the same.The subpopulation that cannot be eliminated thoroughly is known as persisters.More and more studies suggest that persisters seem to play the main role in the recalcitrance of chronic infections.This paper reviewed the biological characteristics and the generation mechanism of persisters and their tolerance mechanism to antibiotic,as well as the strategy to eliminate them.

Key words: persisters, tolerance, resistant mutants

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