Abstract: Objective To investigate the clinical feasibility of immediate loading in edentulous patients and evaluate the clinical effect of treatment. Methods 22 edentulous patients from January 2012 to March 2015 were enrolled. Totally 140 implants were inserted and were immediate loaded within 48 hours by fixed provisional prosthesis. Then, the permanent restorations were performed 4 to 6 months later. Afterwards, survival rate of implants, marginal bone absorption level, implant stability, condition of gingival tissue around implants and degree of satisfaction of the patients were observed and evaluated. Results A total of 140 implants were loaded immediately. Three implants failed and the survival rate was 97.9% (137/140). The average marginal bone absorption was (0.62±0.11)mm in six months and (0.74±0.13)mm in twelve months. During the follow-up period, mechanical complications occurred in 4 patients, such as provisional prosthesis fracture, relining, the artificial teeth crack and so on. Healthy gingival tissue around implants was seen. The dentures were stable and function of chewing was restored well. Patients were satisfied with the clinical treatment. Conclusion Choosing appropriate cases, the immediate loading in edentulous patients using surgical and restorative techniques is predictable. An ideal and reliable clinical efficacy can be obtained in the short and medium term.