种植体周龈沟液IL-17A和IL-35水平检测及意义

Abstract

Abstract: Abstract: Objective To analyze the similarities and differences of the expression of interleukin (IL)-17A and IL-35 between the group of peri-implantitis and peri-implant healthy patients, and to explore the mutual relationship and effect of IL-17A and IL-35 on the development and progress in peri-implantitis. Methods Peri-implant sulcular fluid (PISF) was collected from 20 subjects with healthy implants, and 20 with implantitis. The latter was made as comparison group after the implantitis was treated. The concentrations of IL-17A and IL-35 were determined by enzyme-linked immunosorbent assay method. Bleeding on probing (BOP), modified sulcus bleeding index (mSBI) and gingival index (GI) from the healthy implant group, the peri-implantitis group and the treated group were recorded and analyzed statistically. Results The concentrations of IL-17A and IL-35 in the peri-implantitis group were significantly higher than those in the healthy implant group (P<0.05). IL-17A was slightly lower after treatment (P<0.05), and IL-35 was slightly higher after treatment (P<0.05). The concentrations of IL-17A and IL-35 were negatively correlated in the eri-implantitis group. Conclusion The expressions of IL-35 and IL-17A are are closely related with the occurrence and development of peri-implantitis. IL-17A and IL-35 are potential molecular biological markers that may help assist diagnosis and treatment of implantitis.

Key words: implant, interleukin, peri-implant sucular fluid

CLC Number:

R781.4

References

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The significance and level detection of altered IL-17A and IL-35 in peri-implant gingival crevicular fluid

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