Abstract: Abstract： Objective To preliminarily evaluate the biological safety of nanoreinforced （NF） alumina ceramic. Methods According to ISO 7405/GB 16886 standards， vitro cytotoxicitytest （agar diffusion test）， acute haemolysistest， oral mucus membrane stimulation test and acute systemic toxicity test were carried out to evaluate the biological safety of NF alumina ceramic. Results NF alumina ceramic had no cytotoxicity effect in vitro agar diffusion test. The result of acute haemolysis test was 0.275%， far lower than 5%， which indicated the negative results of heamolysis test. The grade of oral mucous membrane stimulation test in mesocricetus auratus was only 0， which was considered no irritation to mucous membrane according to medical standard. In acute systematic toxicity tests， all of the tested mice survived. By HE staining， no abnormality was observed in kidney and liver tissues. Conclusion NF alumina ceramic is preliminarily proved safe for dental application.

Key words: dental ceramic, alumina ceramic, biocompatibility