白细胞介素-21在不同牙周状态龈沟液中的表达及相关性分析

Abstract

Abstract: Abstract: Objective To investigate the concentration of IL-21 in gingival crevicular fluid (GCF) and the correlation between IL-21 and periodontal clinical parameters to discuss the possible role of IL-21 in different types of periodontitis. Methods 15 healthy people were included as control group, 10 patients with slight periodontitis were selected as slight periodontitis group, and 22 patients with moderate or severe chronic periodontitis were selected as moderate or severe periodontitis group. The basic information was recorded, and probing depth (PD) and clinical attachment level (CAL) were detected by Florida periodontal probes. GCF was collected from patients in each group. The IL-21 protein in GCF was determined by Enzyme Linked Immunosorbent Assay (ELISA). Pearson rank correlation and SPSS19.0 software was used for statistical analysis. Results The mean concentration of IL-21 protein in GCF of each group was (107.20±2.54) pg/mL, (218.90±5.11) pg/mL, and (367.80±7.27 ) pg/mL; The concentration of IL-21 in both periodontitis groups were significantly higher than that in the control group (P < 0.05), and the highest concentration of IL-21 was demonstrated in the moderate or severe periodontitis group. There was significant positive correlation between IL-21 and PD or CAL (P < 0.001). Conclusion The IL-21 protein in GCF of periodontitis is high, especially in moderate or severe chronic periodontitis. IL-21 may play a vital role in periodontal disease, which is related with the destruction of periodontal tissues.

Key words: Interleukin-21, Gingival crevicular fluid, Chronic periodontitis

CLC Number:

R781.4.2

References

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The expression and correlation of IL-21 in GCF with different types of periodontitis

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