GDF15对成血管和成骨/破骨作用的影响及机制的研究进展

Abstract

Abstract: GDF-15 (also MIC-1, NAG-1, PLAB, PTGFβ) is a member of the TGF-β superfamily, which is widely distributed in mammalian tissues and has received considerable attention revealing a remarkable multifunctional role in controlling biological events. The progress of bone repair and regeneration is closely associated with angiogenesis. The function of GDF15 on angiogenesis and bone metabolism are diverse, depending on the interaction with their microenvironment, and its signaling pathways remain poorly understood. GDF15 may serve as a therapeutic target for bone regeneration and cancer bone metastases.

Key words: Growth differentiation factor 15, Angiogenesis, Bone metabolism, Signaling pathway

CLC Number:

　R329.29

References

[1]Kim JM,Kosak JP,Kim JK,et al.NAG-1/GDF15 transgenic mouse has less white adipose t and a reduced inflammatory response[J].Mediators Inflamm,2013,2013:641851-
[2]Mazagova M,Buikema H,van Buiten A,et al.Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes[J].Am J Physiol Renal Physiol,2013,305(9):F1249-1264
[3]Tsai VW,Macia L,Johnen H,et al.TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator[J].PloS one,2013,8(2):e55174-
[4]Baek SJ,Okazaki R,Lee SH,et al.Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia[J].Gastroenterology,2006,131(5):1553-1560
[5]Shnaper S,Desbaillets I,Brown DA,et al.Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome[J].Int J Cancer,2009,125(11):2624-2630
[6]Zhao L,Lee BY,Brown DA,et al.Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling[J].Cancer Res,2009,69(19):7696-7703
[7]Zhang L,Yang X,Pan HY,et al.Expression of growth differentiation factor 15 is positively correlated with histopathological malignant grade and in vitro cell proliferation in oral squamous cell carcinoma[J].Oral Oncol,2009,45(7):627-632
[8]Xue H,Lu B,Zhang J,et al.Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach[J].J Proteome Res,2010,9(1):545-555
[9]Wallin U,Glimelius B,Jirstrom K,et al.Growth differentiation factor 15: a prognostic marker for recurrence in colorectal cancer[J].Br J Cancer,2011,104(10):1619-1627
[10]Staff AC,Trovik J,Eriksson AG,et al.Elevated plasma growth differentiation factor-15 correlates with lymph node metastases and poor survival in endometrial cancer[J].Clin Cancer Res,2011,17(14):4825-4833
[11]Tan M,Wang Y,Guan K,et al.PTGF-beta,a type beta transforming growth factor (TGF-beta) superfamily member,is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway[J].Proc Natl Acad Sci U S A,2000,97(1):109-114
[12]Liggett JL,Zhang X,Eling TE,et al.Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets[J].Cancer Lett,2014,346(2):217-224
[13]Baek SJ,Wilson LC and Eling TE.Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53[J].Carcinogenesis,2002,23(3):425-434
[14]Bottone FG,Jr.,Baek SJ,Nixon JB,et alDiallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells[J].. J Nutr,2002,132(4):773-778
[15]Wilson LC,Baek SJ,Call A,et al.Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells[J].Int J Cancer,2003,105(6):747-753
[16]Min KW,Zhang X,Imchen T,et al.A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4[J].Toxicol Appl Pharmacol,2012,263(2):225-232
[17]Bootcov MR,Bauskin AR,Valenzuela SM,et al.MIC-1,a novel macrophage inhibitory cytokine,is a divergent member of the TGF-beta superfamily[J].Proc Natl Acad Sci U S A,1997,94(21):11514-11519
[18]Zhang Z,Wu L,Wang J,Li G,et al.Opposing effects of PI3K/Akt and Smad-dependent signaling pathways in NAG-1-induced glioblastoma cell apoptosis[J].PLoS One,2014,9(4):e96283-
[19]Derynck R,Zhang YE.Smad-dependent and Smad-independent pathways in TGF-beta family signalling[J].Nature,2003,425(6958):577-584
[20]Min KW,Liggett JL,Silva G,et al.NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway[J]. Oncogene 2015,Epub ahead of print
[21]Xu J,Kimball TR,Lorenz JN,et al.GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation[J].Circ Res,2006,98(3):342-350
[22]Ferrari N,Pfeffer U,Dell'Eva R,et al.The transforming growth factor-beta family members bone morphogenetic protein-2 and macrophage inhibitory cytokine-1 as mediators of the antiangiogenic activity of N-(4-hydroxyphenyl)retinamide[J].Clin Cancer Res,2005,11(12):4610-4619
[23]Whitson RJ,Lucia MS and Lambert JR.Growth differentiation factor-15 (GDF-15) suppresses in vitro angiogenesis through a novel interaction with connective t6 growth factor (CCN2)[J].J Cell Biochem,2013,114(6):1424-1433
[24]Tsui KH,Hsu SY,Chung LC,et al.Growth differentiation factor-15: a p53- and demethylation-upregulating gene represses cell proliferation,invasion,and tumorigenesis in bladder carcinoma cells[J].Sci Rep,2015,5:12870-
[25]Song H,Yin D and Liu Z.GDF-15 promotes angiogenesis through modulating p53/HIF-1alpha signaling pathway in hypoxic human umbilical vein endothelial cells[J].Mol Biol Rep,2012,39(4):4017-4022
[26]Kempf T,Eden M,Strelau J,et al.The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury[J].Circ Res,2006,98(3):351-360
[27]Zhang M,Pan K,Liu Q,et al.Growth differentiation factor 15 may protect the myocardium from noreflow by inhibiting the inflammatorylike response that predominantly involves neutrophil infiltration[J].Mol Med Rep,2016,13(1):623-632
[28]Mueller M,Giannitsis E,Katus HA.Essential cardiac biomarkers in myocardial infarction and heart failure[J].Herz,2014,39(6):727-739
[29]Albertoni M,Shaw PH,Nozaki M,et al.Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1[J].Oncogene,2002,21(27):4212-4219
[30]Jin YJ,Lee JH,Kim YM,et al.Macrophage inhibitory cytokine-1 stimulates proliferation of human umbilical vein endothelial cells by up-regulating cyclins D1 and E through the PI3K/Akt-,ERK-,and JNK-dependent AP-1 and E2F activation signaling pathways[J].Cell Signal,2012,24(8):1485-1495
[31]Huh SJ,Chung CY,Sharma A,et al.Macrophage inhibitory cytokine-1 regulates melanoma vascular development[J].Am J Pathol,2010,176(6):2948-2957
[32]Kim KK,Lee JJ,Yang Y,et al.Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells[J].Carcinogenesis,2008,29(4):704-712
[33]Fayard B,Loeffler S,Weis J,et al.The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC[J].J Neurosci Res,2005,80(1):18-28
[34]Li J,Yang L,Qin W,et al.Adaptive induction of growth differentiation factor 15 attenuates endothelial cell apoptosis in response to high glucose stimulus[J].PloS one,2013,8(6):e65549-
[35]Tchou I,Margeli A,Tsironi M,et al.Growth-differentiation factor-15,endoglin and N-terminal pro-brain natriuretic peptide induction in athletes participating in an ultramarathon foot race[J].Biomarkers,2009,14(6):418-422
[36]Cappellen D,Luong-Nguyen NH,Bongiovanni S,et al.Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B[J].J Biol Chem,2002,277(24):21971-21982
[37]Weivoda MM,Ruan M,Pederson L,et al.Osteoclast TGF-beta Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation[J/OL]. J Bone Miner Res,2015,[2016-01-10]. doi: 10.1002/jbmr.2586
[38]Crane JL,Xian L,Cao X.Role of TGF-beta Signaling in Coupling Bone Remodeling[J].Methods Mol Biol,2016,1344:287-300
[39]Sanchez-Duffhues G,Hiepen C,Knaus P,et al.Bone morphogenetic protein signaling in bone homeostasis[J].Bone,2015,80:43-59
[40]Chen G,Deng C,Li YP.TGF-beta and BMP signaling in osteoblast differentiation and bone formation[J].Int J Biol Sci,2012,8(2):272-288
[41]Hinoi E,Ochi H,Takarada T,et al.Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia[J].J Bone Miner Res,2012,27(4):938-949
[42]Wang Y,Wan C,Deng L,et al.The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development[J].J Clin Invest,2007,117(6):1616-1626
[43]Wagegg M,Gaber T,Lohanatha FL,et al.Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner[J].PLoS One,2012,7(9):e46483-
[44]Zhang W,Zhu C,Wu Y,et al.VEGF and BMP-2 promote bone regeneration by facilitating bone marrow stem cell homing and differentiation[J].Eur Cell Mater,2014,27:1-11
[45]Liu Y,Berendsen AD,Jia S,et al.Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation[J].J Clin Invest,2012,122(9):3101-3113
[46]Vanhara P,Lincova E,Kozubik A,et al.Growth/differentiation factor-15 inhibits differentiation into osteoclasts--a novel factor involved in control of osteoclast differentiation[J].Differentiation,2009,78(4):213-222
[47]Li N,Karin M.Signaling pathways leading to nuclear factor-kappa B activation[J].Methods Enzymol,2000,319:273-279
[48]Wakchoure S,Swain TM,Hentunen TA,et al.Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss[J].Prostate,2009,69(6):652-661

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