骨相关细胞的自噬及其在口腔种植中的作用

Abstract

Abstract: Autophagy is a highly conserved cellular process in which organelles, proteins and other cytoplasmic components are delivered to lysosomes for degradation. Recently, there came some studies which had demonstrated that autophagy is essential for bone cell homeostasis. Mutations in autophagy receptors will lead to the imbalance between bone formation and resorption. Altering the state of autophagy may change the differentiation of bone marrow derived mesenchymal stem cells and the construction and function of bone. Moreover, clinical success of dental implantation is critically related to the satisfactory osseointegration in which autophagy plays an important role through influencing the peri-implant bone remodeling and regulating bone homeostasis. This review aims to provide a comprehensive overview of autophagy in bone cells and its role in bone metabolic diseases and dental implantation.

Key words: autophagy, bone marrow derived mesenchymal stem cells, osteoblast, osteoclast, osteocyte, dental implant

CLC Number:

R782.12

References

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Autophagy in bone cells and its role in dental implantation

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