›› 2016, Vol. 36 ›› Issue (5): 471-474.

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Mechanism and application of RNA interference in stomatology

  

  • Received:2015-11-09 Revised:2016-02-29 Online:2016-05-28 Published:2016-06-01

Abstract: Abstract: RNA interference (RNAi) is a sequence-specific gene silencing phenomena mediated by double-stranded RNA which involves siRNA (Small interfering RNA) and miRNA (Micro RNA), and it could block gene expression at the level of transcription, post-transcription and translation, with high efficiency and specificity. This review summarized the pathway and technical route, and the application of RNAi in maxillofacial development, cheilopalatognathus researches, periodontal tissue development and oral tumor researches in stomatology.

Key words: RNAi (RNA interference), siRNA( Small interfering RNA), miRNA (Micro RNA), gene silence, stomatology

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