Abstract: Abstract：Human periodontal ligament stem cells (hPDLSCs), which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are able to induce osteogenic differentiation under specific condition.The periodontium exists in a hypoxic microenvironment and the hPDLSCs constitutively receive mechanical stress. The aim of this review is to get the laboratory data of periodontal tissue reconstruction by reviewing relevant literature that assesses the effects of tensile stress on osteogenic differentiation of hPLSCs under hypoxia.

Key words: human periodontal ligament stem cells, hypoxia, mechanical stress, osteogenic differentiation