口腔扁平苔藓患者血清IFN-γ、IL-10和IL-17表达分析

Abstract

Abstract: Objective To observe the expression of Th cytokines IFNγ, IL10 and IL17 in serum of patients with oral lichen planus (OLP), and to explore its role in the genesis and development of OLP. Methods 15 patients with OLP and 15 healthy controls participated in the study. Interferon (IFN)γ, interleukin (IL)10 and IL17 levels in serum were examined by enzyme linked immunosorbent assay (ELISA). Results The levels of Th1 cytokines IFNγ in serum of patients with OLP group and healthy controls were （20.8±8.3）pg/mL and （20.6±3.1）pg/mL, respectively, with no statistical difference between groups (P>0.05). The levels of Th2 cytokines IL10 in serum of patients with OLP and healthy controls were （43.3±4.6）pg/mL and （29.0±5.1）pg/mL, respectively, and the difference was statistically significant (P<0.05). The ratio of IFNγ to IL10 was 0.418 for the OLP group and 0.712 for the control group, which demonstrated a decrease in the experimental group compared the control group. The level of Th17 cytokines IL17 in serum of patients with OLP group was （23.6±2.7）pg/mL, which was significantly higher than （16.8±3.3）pg/mL in the control group (P<0.05). Conclusion The change in Th cytokines balance is involved in the pathogenesis of OLP.

Key words: oral lichen planus, serum, cytokine

CLC Number:

R781.5

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Expression of IFN-γ, IL-10 and IL-17 in patients with oral lichen planus

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