牙周干预治疗对牙周炎伴冠心病患者血脂水平及炎症因子的影响

Abstract

Abstract: Objective To investigate the effects of non-surgical periodontal treatment on lipid levels and inflammatory factors in patients with periodontitis and coronary heart disease. Methods 83 cases of coronary heart disease patients with moderate and severe periodontitis (intervention group) and 50 cases of coronary heart disease patients without periodontitis (control group) were selected. Cases in intervention group received non-surgical periodontal treatment, which included oral hygiene instruction, ultrasound supragingival scaling, subgingival scaling and root planning, while the control group did not receive any intervention. The periodontal statuses of patients in intervention group and control group were assessed. The inflammatory factors in gingival crevicular fluid and serum were all detected by enzyme-linked immunosorbent assay. Results The AL, PD, PLI and BLI of patients in intervention group after treatment were lower than those before treatment (P<0.05). The levels of IL-1β, IL-6 and TNF-α in serum and gingival crevicular fluid in intervention group after treatment were lower than those before treatment (P<0.05). The serum levels of TC, TG and LDL-C in intervention group were lower after treatment, while the levels of HDL-C and adiponectin were higher (P<0.05). Conclusion Non-surgical periodontal treatment could effectively improve periodontal status of patients with coronary heart disease and periodontitis, reduce the body's inflammatory response, and improve lipid metabolism. Thus, it could produce positive effect on the progression of coronary heart disease.

Key words: periodontitis, coronary heart disease, non-surgical periodontal treatment, hyperlipidemia, inflammatory factor

CLC Number:

R781.4+2

References

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Effects of non-surgical periodontal treatment on lipid levels and inflammatory factors in patients with periodontitis and coronary heart disease

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