Abstract: Abstract Objective To systematically evaluate the efficacy and safety of tacrolimus and glucocorticoid for oral lichen planus(OLP)， in order to provide strong basis for clinical rational use of drugs and prevention of adverse reactions.Methods The Cochrane review’s method was adopted manual and computer—based retrieval was performed on The PubMed ,Cochrane Library, MEDLINE，EMbase，CBM，VIP， CNKI and WanFang Data (from their establishment toJune 2016)to collect randomized controlled trials comparing the clinical efficacy of tacrolimus in treating OLP with that of glucocorticoid．The study was selected according to Cochrane system evaluation method． Fifteen literature is recommended by Cochrane was used to complete the Meta analysis of total effective rate ，recurrence rate and rate of adverse reaction. Results Fifteen trials involving 894 patients were included． The results of meta-analyses showed that the total effective rate of tacrolimus was higher than that of triamcinolone acetonide (RR=1．55，95％CI(1．27，1．89)，P＜0.0001) ，mometasone （RR=1．27，95％CI(1．16，1．39)，P＜0.00001) ，and fluorine relaxed (RR=1．33，95％CI(1．05，1．69)，P=0.02)，but there was no significant difference between the tacrolimus group and the propionate group(RR=1．04，95％CI(0.95，1．14)，P=0.44). However,there was no significant difference between the tacrolimus group and the glucocorticoid group in adverse events(RR=0．66，95％CI(0．38，1．15),P=0.14) , there was a significant difference between the experience group and the control group in recurrence rate(RR=0．70，95％CI(0．49，1．00),P=0.05) during the treatment session. Conclusion Current evidence shows that, tacrolimus treated oral lichen planus is a short-term clinical curative effect of better treatment plan. While the diagnosis of pathological examination by pathological examination was less,Due to the limited quality of included studies ,the possibility of selective migration increased.it still needs to be verified by more high quality studies to increase the efficacy and safety of the medicine.

Key words: Key words Tacrolimus, Oral lichen planus, Therapy, Glucocorticoid, Systematic review