牙周基础治疗对口腔扁平苔藓患者血清中白细胞介素10及转化生长因子β的影响

Abstract

Abstract: Abstract Objective To investigate the effect of the periodontal basic therapy on patients with both oral lichen planus(OLP) and periodontitis through observation of the levels of interleukin-10 and transforming growth factor-β (TGF-β) in serum before and after treatment, and to discuss the meaning of periodontal intervention in the treatment of oral lichen plan. Methods: 40 patients with both OLP and periodontitis were divided into two groups: periodontal treatment group (20 patients) and non-periodontal treatment group (20 patients), then the two groups were given periodontal therapy combined with drug therapy and drug treatment only, respectively. Probing depth (PD), attachment loss (AL), bleeding indices (bleeding index,BI) and levels of IL-10 and TGF-β were detected at the baseline and one month after treatment. Results After treatment, PD and BI except AL were lower than before treatment (P<0.05) in periodontal treatment group. There were no significant differences in PD and AL in non-periodontal treatment group before and after treatment (P>0.05); in contrast, BI after treatment was higher than before treatment (P<0.05). In periodontal treatment group, the expression level of TGF-β in serum decreased after treatment and the difference was statistically significant (P<0.05); however, the level of IL-10 had no significant difference before and after periodontal treatment (P>0.05). The levels of IL-10 and TGF-β had no statistically significant differences before and after treatment in non-periodontal treatment group (P>0.05).Conclusion The periodontal basic therapy can affect the level of TGF-β in the serum of patients with both OLP and periodontitis. Periodontal basic treatment can be used as one of the auxiliary treatment to control the disease development, but the long-term effect is worth further observation. Conclusion: The periodontal basic therapy can affect the serum level of TGF-β in patients with both OLP and periodontitis, periodontal basic treatment can be used as one of the auxiliary treatment to control the disease development, but the long-term effect is worth further observation.

Key words: Oral Lichen Planus, Periodontitis, Periodontal basic therapy, TGF-β, Interleukin-10

CLC Number:

R781.05

References

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Impact of basic periodontal therapy on the peripheral blood IL-10 and TGF-β levels in oral lichen planus patients

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