Abstract: Objective　To analyze the prognosis of mucoepidermoid carcinoma (MEC) of salivary gland and to explore the clinicopahtological influencing factors. Methods　78 patients with MEC of salivary gland treated with operation in our hospital from January 2001 to February 2016 were retrospectively selected. Related clinicopahtological materials were collected. Postoperative survival rates of 3, 5 and 10 years were calculated by Kaplan-Meier method and prognostic factors were analyzed by Log rank tests and Cox regression model. Results　(1). The overall survival rates of 3, 5, and 10 years were 98.6%, 89.6% and 73.5% among patients with salivary gland MEC respectively after surgical therapy. (2). Univariate analysis: The overall survival rates of patients with high differentiation and no lymphatic metastasis were statistically significantly higher than those of patients with low differentiation (Log-rank=10.03,P<0.01) and lymphatic metastasis (Log-rank=8.57, P=0.01) respectively. (3). Multivariate analysis: Pathological differentiation (HR=12.71; P=0.02) and lymphatic metastasis (HR=6.84; P=0.01) were the independent clinicopahtological influencing factors among patients with salivary gland MEC after operation. Conclusion　Pathological differentiation and lymphatic metastasis are the independent prognostic clinicopathological factors of salivary gland MEC. Comprehensive measures should be taken for patients with poorly differentiation or lymphatic metastasis to improve the postoperative prognosis.

Key words: Salivary gland, Mucoepidermoid carcinoma, Prognosis, Influencing factors.