Abstract: Abstract: Periodontitis is a chronic inflammatory disease induced by dental plaque. The disease implicates damage to the tooth-supporting tissues, causing the tooth mobility, even tooth loss. Forkhead box O1 is at the crossroads of many signal transduction pathways. As a critical signaling integrators, FOXO1 can regulate a number of important host cell progress including oxidative stress response, cell cycle, apoptosis and autophagy. Recently, studies have demonstrated the potential role of FOXO1 in the occurrence and progression of periodontitis. FOXO1 may involve in regulating innate immune responses, oxidative stress responses and alveolar bone remodeling directly and indirectly by interacting with protein kinase B, c-Jun N-terminal kinase and activating transcriptional factor 4. Thus, uncovering the role of FOXO1 in periodontitis development would be a big step towards treatment of the periodontitis.

Key words: Key words：Periodontitis, Forkhead box O, inflammation, Oxidative stress, Bone remodeling