Abstract: Zinc oxide nanoparticles is a versatile new inorganic material, the particle size of about 1 ~ 100nm.Because of the fineness of particles, the surface electronic structure and crystal structure changed, the surface effect, the macroscopic objects do not have the volume effect, quantum size effect and macroscopic tunnel effect, with high transparency, high dispersion and other characteristics.In recent years with the nano-zinc oxide antibacterial effect of in-depth study, its application in the medical field gradually increased.,In this paper, the antimicrobial effect of nano-zinc oxide in medical applications to do a review and prospects.

Key words: Zinc Oxide Nanoparticles，Antibacterial Activity，Antibacterial mechanism，Application