›› 2017, Vol. 37 ›› Issue (11): 997-1001.

• Basic Research • Previous Articles     Next Articles

Preparation of folate-chitosan loaded decitabine nanoparticles and targeting inhibition effect on tongue carcinoma cells

  

  • Received:2017-04-12 Revised:2017-05-12 Online:2017-11-28 Published:2017-11-24

Abstract: Objective To prepare stable DAC loaded folate-chitosan nanoparticles and explore the inhibition effect on SCC-9.Methods DAC loaded folate-chitosan nanoparticles were prepared by ionically cross-linking method. The physicochemical properties of the obtained NPs were characterized by dynamic light-scattering analysis for their mean size, size distribution, loading ratio, encapsulation efficiency and zeta potential; transmission electron microscopy for surface morphology; the nanoparticles were targeted to detect their effect on cells of tongue tumor SCC-9.Results The average particle size of The nanoparticles was 212 nm. Zeta potential was 31.8mv.The drug encapsulation efficiency(EE) was 75%,and loading capacity(LC) was 18%. The DAC/FA-CS-NPs exhibited better than DAC alone. Conclusion The DAC loaded FA–CS nanoparticles are stable, loading ratio and encapsulation efficiency are higher and can target at and inhibit SCC-9.

Key words: folate, chitosan, decitabine, tongue cancer

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