Abstract: Objective Using digital design (referred to as DSD) according to oral and maxillofacial aesthetics principles, through computer simulation analysis and design software, the tooth shape and arrangement can be expressed artistically in a virtual state. The medical team and patients can predict and communicate the treatment outcome well before the treatment, and the unified treatment plan designed by both doctors and patients can guide the whole treatment process. Methods From October 2014 to October 2016, 50 patients with anterior teeth discoloration, tooth defect and uneven dentition were treated under DSD design guidance. The treatment effect was analyzed. Results Aesthetics evaluation was conducted in accordance with Howard B.Kay’s Classification of Altered Dental Esthetics, and all treatments met the requirements of the earlier DSD design. At the same time, the treatment results were satisfactory, and all the patients were satisfied with the shape of the front teeth. There were 3 patients who wanted brighter colors and reworked their bleached white color. Functional occlusion basically mimicked the shape of a temporary restoration, with only a small amount of adjustment needed. Conclusion DSD plays an important role in the esthetic restoration of the anterior teeth. It guides the whole process of the treatment and improves the satisfaction of the patients.