Abstract: Multiple myeloma (MM) is a monoclonal malignant proliferation disease of plasma cells. The disease is more frequently in men and affects individuals aged from 60 to 70 years old. The initial manifestation of MM is various and depends on the sites and extent of involvement. Its occurrence in the maxilla and/or mandible is very common, however oral lesions rarely appear as the first manifestation of the disease. This paper reported a case of a 55 years old female who had a chief complaint of a mass in the right maxilla and the chin numbness. Contrast-enhanced CT and PET/CT scanning showed middle cranial fossa and maxilla and mandible bone diffuse destructive lesions. The biopsy results, imaging and physical examination led to the diagnosis of MM. The findings of the case report suggest that MM should be included in the differential diagnosis and related radiographic and laboratory evaluation should be administered when considering a patient whose complaint is an unusual maxillary and/or mandibular mass.

Key words: multiple myeloma, maxilla mass, chin numbness, differential diagnosis