Abstract: Patients with diabetes have increased incidence, severity of periodontal disease ,which is regarded as a serious complication of diabetes mellitus. Advanced glycation end of products (AGEs) is formed by irreversible reaction of reductase with protein. It plays an important role in the pathogenesis of diabetic chronic complication. In autophagy, damaged organelles and proteins are transported to lysosomes for degradation and recycling, aiming to maintain a homeostatic environment. This process is a highly defensive mechanism among eukaryotic cells. The study of autophagy in mammalian systems is advancing rapidly and has revealed that it is involved in the pathogenesis of various metabolic and age-related diseases. However, the mechanism of autophagy and periodontal destruction in relation to diabetesis unclear. This review focuses on the potential relations between autophagy and periodontitis associated with diabetes mellitus.

Key words: periodontitis associated with diabetes mellitus, autophagy, advanced glycation end of products