微小RNA与肿瘤坏死因子-α对成骨分化调控作用研究进展

Abstract

Abstract: Abstract: Periodontitis often result in massive bone destruction and show increased incidences especially in elderly population. As one of the highly-expressed inflammatory mediators, tumor necrosis factor-alpha (TNF-α), together with a certain group of microRNAs (miRNAs), have recently been shown to play important roles in regulating osteogenic differentiation in inflammatory microenvironment. This review summarized progresses in the understanding of the molecular mechanisms underlying the regulatory effets of microRNA and TNF-α on osteogenic differentiation.

Key words: microRNA, tumor necrosis factor-alpha, osteogenic differentiation

CLC Number:

R780.2

References

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Review of study in regulatory effects of microRNAs and tumor necrosis factor-alpha on osteogenic differentiation

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